A Retrospective Review of the Prognostic Value of ALDH-1, Bmi-1 and Nanog Stem Cell Markers in Esophageal Squamous Cell Carcinoma
| العنوان: | A Retrospective Review of the Prognostic Value of ALDH-1, Bmi-1 and Nanog Stem Cell Markers in Esophageal Squamous Cell Carcinoma |
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| المؤلفون: | Jim-Ray Chen, Siu-Cheung Chan, Cheng-Cheng Hwang, Wen-Ying Chi, Hui-Ping Chien, Liang-Che Chang, Chien-Hong Lai, Chung-Ching Hua, Tsan-Yu Hsieh, Chih-Wei Wang, Shin Nieh, Chien-Sheng Tsai |
| المصدر: | PLoS ONE, Vol 9, Iss 8, p e105676 (2014) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Homeobox protein NANOG, Pathology, medicine.medical_specialty, Esophageal Neoplasms, lcsh:Medicine, Stem cell marker, Aldehyde Dehydrogenase 1 Family, Disease-Free Survival, Animal Cells, Diagnostic Medicine, Cancer stem cell, Medicine and Health Sciences, Biomarkers, Tumor, Carcinoma, Humans, Medicine, lcsh:Science, Survival rate, Aged, Retrospective Studies, Homeodomain Proteins, Polycomb Repressive Complex 1, Multidisciplinary, business.industry, Stem Cells, lcsh:R, Biology and Life Sciences, Retinal Dehydrogenase, Nanog Homeobox Protein, Cell Biology, Middle Aged, Esophageal cancer, Prognosis, medicine.disease, Neoplasm Proteins, Isoenzymes, Survival Rate, Carcinoma, Squamous Cell, Neoplastic Stem Cells, Cancer research, Immunohistochemistry, Female, lcsh:Q, Cellular Types, business, Research Article |
| الوصف: | Stem cell markers are upregulated in various cancers and have potential as prognostic indicators. The objective of this study was to determine the expression of three stem cell markers, aldehyde dehydrogenase 1 (ALDH-1), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1), and Nanog, in esophageal squamous cell carcinoma (ESCC) tissues. Immunohistochemistry was used to measure the expression of ALDH-1, Bmi-1, and Nanog in ESCC tissues from 41 patients who received pre-operative chemoradiation. We evaluated the relationship between expression of these markers, and clinicopathological features, tumor regression grade (TRG), and 5-year overall survival (OS). There were no significant associations of ALDH-1 or Bmi-1 expression with age, gender, clinical stage, and treatments (p>0.05). However, patients with Nanog-positive tumors were significantly older than those whose tumors were Nanog-negative (p = 0.033). TRG after treatment was significantly associated with expression of ALDH-1 (p = 0.001), Bmi-1 (p = 0.004), and Nanog (p |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff48182cd6599670e4afc6eeeecbfc09Test https://doi.org/10.1371/journal.pone.0105676Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ff48182cd6599670e4afc6eeeecbfc09 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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