Expression of programmed death ligand-1 and programmed death 1 in hepatocellular carcinoma and its clinical significance
| العنوان: | Expression of programmed death ligand-1 and programmed death 1 in hepatocellular carcinoma and its clinical significance |
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| المؤلفون: | X Tang, Yan-Hua Xu, P Qiu, Tao Qu, XF Pan, J Long, HH Wan |
| المصدر: | Journal of Cancer Research and Therapeutics, Vol 14, Iss 12, Pp 1188-1192 (2018) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, programmed death ligand-1, Stromal cell, Carcinoma, Hepatocellular, Hepatocellular carcinoma, Lymphocyte, Programmed Cell Death 1 Receptor, lcsh:RC254-282, B7-H1 Antigen, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, medicine, Biomarkers, Tumor, Humans, Radiology, Nuclear Medicine and imaging, Clinical significance, Aged, Neoplasm Staging, programmed death 1, business.industry, Liver Neoplasms, General Medicine, Middle Aged, medicine.disease, Ligand (biochemistry), Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Survival Analysis, 030104 developmental biology, medicine.anatomical_structure, Oncology, Liver, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Cancer research, Disease Progression, Immunohistochemistry, Biomarker (medicine), Female, Lymph Nodes, business, Follow-Up Studies |
| الوصف: | Objective: To investigate the correlation between the expression of programmed death 1 (PD-1) and PD ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) and clinical parameters. Materials and Methods: The study comprised tumor sections from 45 HCC patients treated with curative resection, which were evaluated for PD-1 and PD-L1 protein expression by immunohistochemistry. Results: PD-1 and PD-L1 expression was increased in cancers compared to adjacent normal tissues, with a positive rate of 37.78% (17/45) and 62.22% (28/45), respectively, which was positively correlated with the tumor stage and lymph node metastasis, negatively with postoperative prognosis. PD-1 positivity was most frequently observed in stromal tumor-infiltrating lymphocytes. The number of PD-1 positive lymphocyte was correlated with PD-L1 positive expression. Conclusion: PD-L1 and PD-1 are overexpressed in HCC tissues. PD-L1 expression plays a critical role in the pathogenesis of human HCC, suggesting that it might be used as a new biomarker to predict the disease progression and prognosis. |
| اللغة: | English |
| تدمد: | 1998-4138 0973-1482 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea1a3878dbbd4fa8454ee2cc076f546Test http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=12;spage=1188;epage=1192;aulastTest= |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fea1a3878dbbd4fa8454ee2cc076f546 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19984138 09731482 |
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