Human perceptual learning is delayed by the N-methyl-D-aspartate receptor partial agonist D-cycloserine
| العنوان: | Human perceptual learning is delayed by the N-methyl-D-aspartate receptor partial agonist D-cycloserine |
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| المؤلفون: | Harriet Dempsey-Jones, Tamar R. Makin, Marcella L. Woud, Susann Steudte-Schmiedgen, Juergen Margraf, Andrea Reinecke, Catherine J. Harmer, Michael Browning |
| المصدر: | Journal of Psychopharmacology (Oxford, England) |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Time Factors, Adolescent, D-cycloserine, Receptors, N-Methyl-D-Aspartate, Partial agonist, Young Adult, 03 medical and health sciences, Cognition, 0302 clinical medicine, Double-Blind Method, somatosensory plasticity, psychophysics, Perceptual learning, Humans, Learning, Medicine, Pharmacology (medical), Longitudinal Studies, Receptor, Brain function, Psychological treatment, Pharmacology, D aspartate, business.industry, touch perception, Original Papers, 030227 psychiatry, Drug Partial Agonism, Psychiatry and Mental health, Cycloserine, N-methyl-D-aspartate, Female, cognitive enhancement, business, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Background: The optimisation of learning has long been a focus of scientific research, particularly in relation to improving psychological treatment and recovery of brain function. Previously, partial N-methyl-D-aspartate agonists have been shown to augment reward learning, procedural learning and psychological therapy, but many studies also report no impact of these compounds on the same processes. Aims: Here we investigate whether administration of an N-methyl-D-aspartate partial agonist (D-cycloserine) modulates a previously unexplored process – tactile perceptual learning. Further, we use a longitudinal design to investigate whether N-methyl-D-aspartate-related learning effects vary with time, thereby providing a potentially simple explanation for apparent mixed effects in previous research. Methods: Thirty-four volunteers were randomised to receive one dose of 250 mg D-cycloserine or placebo 2 h before tactile sensitivity training. Tactile perception was measured using psychophysical methods before and after training, and 24/48 h later. Results: The placebo group showed immediate within-day tactile perception gains, but no further improvements between-days. In contrast, tactile perception remained at baseline on day one in the D-cycloserine group (no within-day learning), but showed significant overnight gains on day two. Both groups were equivalent in tactile perception by the final testing – indicating N-methyl-D-aspartate effects changed the timing, but not the overall amount of tactile learning. Conclusions: In sum, we provide first evidence for modulation of perceptual learning by administration of a partial N-methyl-D-aspartate agonist. Resolving how the effects of such compounds become apparent over time will assist the optimisation of testing schedules, and may help resolve discrepancies across the learning and cognition domains. |
| تدمد: | 1461-7285 0269-8811 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7020efff7517c4f96c6a22c0b708d9Test https://doi.org/10.1177/0269881120986349Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe7020efff7517c4f96c6a22c0b708d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14617285 02698811 |
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