Postprandial Fatty Acid Profile, but Not Cardiometabolic Risk Markers, Is Modulated by Dairy Fat Manipulation in Adults with Moderate Cardiovascular Disease Risk: The Randomized Controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) Study
| العنوان: | Postprandial Fatty Acid Profile, but Not Cardiometabolic Risk Markers, Is Modulated by Dairy Fat Manipulation in Adults with Moderate Cardiovascular Disease Risk: The Randomized Controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) Study |
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| المؤلفون: | Susan Todd, Kirsty E. Kliem, D.I. Givens, Rachel Sutton, David J. Humphries, Kim G. Jackson, Colette C. Fagan, Alistair S. Grandison, Dafni Vasilopoulou, Oonagh Markey, Julie A. Lovegrove |
| المصدر: | The Journal of Nutrition |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Brachial Artery, Saturated fat, Medicine (miscellaneous), sequential test meal protocol, 030209 endocrinology & metabolism, AcademicSubjects/MED00060, 03 medical and health sciences, 0302 clinical medicine, Animal science, endothelial function, medicine.artery, medicine, Humans, saturated fatty acids, Brachial artery, Triglycerides, Cardiometabolic risk, chemistry.chemical_classification, postprandial lipemia, Cross-Over Studies, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, monounsaturated fatty acids, Fatty Acids, Area under the curve, Fatty acid, Middle Aged, Postprandial Period, Dietary Fats, Cholesterol, Postprandial, chemistry, Cardiovascular Diseases, Saturated fatty acid, Fatty Acids, Unsaturated, Disease risk, AcademicSubjects/SCI00960, Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions, business |
| الوصف: | Background: Chronic consumption of dairy products with a saturated fatty acid (SFA)-reduced, monounsaturated fatty acid (MUFA)-enriched content was shown to impact favourably on brachial artery flow-mediated dilatation (FMD). However, their acute effect on postprandial cardiometabolic risk biomarkers requires investigation.\ud \ud Objective: The effects of sequential high-fat mixed meals rich in fatty acid (FA)-modified or conventional (control) dairy products on postprandial FMD (primary outcome) and systemic cardiometabolic biomarkers in adults with moderate cardiovascular risk (≥50% above population mean) were compared. \ud \ud Methods: In a randomized cross-over trial, fifty-two participants (mean ± SEM age 53 ± 2 y; BMI 25.9 ± 0.5 kg/m2) consumed high-dairy fat breakfast (0 min; ~50 g total fat: Modified: 25 g SFAs, 20 g MUFAs; Control: 32 g SFAs, 12 g MUFAs) and lunch (330 min; ~30 g total fat; Modified: 15 g SFAs, 12 g MUFAs; Control: 19 g SFAs, 7 g MUFAs). Blood samples were obtained before and until 480 min after breakfast, with FMD assessed at 0, 180, 300 and 420 min. Data were analysed by linear mixed models.\ud Results: Postprandial changes in cardiometabolic biomarkers were comparable between the different dairy meals, with the exception of a tendency for a 4% higher area under the curve (AUC) for the %FMD response following the modified dairy fat meals (P = 0.075). Plasma total lipid FA analysis revealed that incremental AUC responses were 53% lower for total SFAs, 214% and 258% higher for total cis-MUFAs (predominantly cis-9 18:1), and trans-18:1 respectively following the modified, relative to control dairy meals (all P < 0.0001). \ud \ud Conclusions: In adults at moderate cardiovascular risk, acute consumption of sequential high-fat meals containing FA-modified dairy products had little impact on postprandial endothelial function or systemic cardiometabolic biomarkers, but a differential effect on the plasma total lipid FA profile, relative to conventional dairy fat meals. |
| وصف الملف: | application/pdf |
| تدمد: | 0022-3166 1541-6100 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5b44601fa02ddc9742c31991ce3752Test https://doi.org/10.1093/jn/nxab050Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe5b44601fa02ddc9742c31991ce3752 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00223166 15416100 |
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