Checkpoint inhibitors: Better outcomes among advanced cutaneous head and neck melanoma patients
| العنوان: | Checkpoint inhibitors: Better outcomes among advanced cutaneous head and neck melanoma patients |
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| المؤلفون: | Michal Lotem, Nir Hirshoren, Nadia Kaplan, Tamar Peretz, Roni Yoeli, Jeffrey M Weinberger, Jonathan Cohen, Sharon Merims |
| المصدر: | PLoS ONE, Vol 15, Iss 4, p e0231038 (2020) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, Melanomas, Skin Neoplasms, Immune checkpoint inhibitors, Programmed Cell Death 1 Receptor, Cancer Treatment, Metastasis, 0302 clinical medicine, Antineoplastic Agents, Immunological, Medicine and Health Sciences, CTLA-4 Antigen, Melanoma, Immune Response, Response rate (survey), Aged, 80 and over, Multidisciplinary, Middle Aged, Treatment Outcome, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Cutaneous Melanoma, Medicine, Female, Anatomy, Research Article, Adult, medicine.medical_specialty, Adolescent, Science, Immunology, Malignant Skin Neoplasms, Dermatology, Lymphatic System, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, Aged, Retrospective Studies, business.industry, Cancers and Neoplasms, Biology and Life Sciences, Retrospective cohort study, medicine.disease, Trunk, Ipilimumab, Survival Analysis, 030104 developmental biology, Cutaneous melanoma, Lymph Nodes, business, Head, Neck, Brain metastasis |
| الوصف: | Objective The aim of this study was to investigate if the treatment outcomes of checkpoint inhibitors (CPI) in patients with advanced-stage skin head and neck melanoma (HNM) differs from outcomes in patients with non-HNM. Design A retrospective cohort study of patients with unresectable AJCC stage III and stage IV, who received CPI between 2010 and 2017. Participants Overall, 122 unresectable AJCC stage III and metastatic stage IV melanoma adult patients were treated with CPI during the study period (consecutive patients). The HNM group of patients was comparable with limbs and trunk melanoma group except different distant metastatic (M1a/b/c/d) pattern (p = 0.025). Main outcomes Comparison of overall survival and clinical response to CPI in patients with advanced-stage skin melanoma of the head and neck with non-HNM. Results We analyzed 38 patients with melanoma arising in the head and neck skin regions, 33 with melanoma of limbs and 51 with trunk melanoma. Most of the head and neck patients were men (89.5%), the average age of melanoma diagnosis was 61.4±16.7 years (range 16.4–85.6). More than a third of HNM group of patients (36.8%) were 70 years and older. Overall response rate (ORR) to CPI was 50% (CR 31.6% and PR 18.4%) in the head and neck study group of patients, compared to an ORR of 36.3% and 23.5% in melanoma of the limbs and of the trunk, respectively (p = 0.03). The median overall survival of HNM group of patients was 60.2±6.3 months, CI 95% [47.7–72.7], 63% were alive at 30 months, reaching a plateau. Whereas, the median survival time of limbs and trunk melanoma were 51.2 and 53.4 months, which did not reach significance. Conclusions and relevance Response rate to CPI is significantly improved in patients with melanoma of the head and neck and they have a trend towards improved, long standing, overall survival. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe54fef35e6b015afeae5046585dbce7Test https://doaj.org/article/63c9c63ea2c84b2cbe0fa668b885d1ecTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe54fef35e6b015afeae5046585dbce7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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