Mechanisms for exporting large-sized cargoes from the endoplasmic reticulum
| العنوان: | Mechanisms for exporting large-sized cargoes from the endoplasmic reticulum |
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| المؤلفون: | Toshiaki Katada, Kota Saito |
| المصدر: | Cellular and Molecular Life Sciences |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Golgi Apparatus, Review, macromolecular substances, Biology, Endoplasmic Reticulum, Models, Biological, GTP Phosphohydrolases, Chylomicron, Cellular and Molecular Neuroscience, symbols.namesake, Antigens, Neoplasm, cTAGE5, Chylomicrons, TANGO1, Animals, Humans, COPII, Secretion, Molecular Biology, Pharmacology, Vesicular-tubular cluster, Endoplasmic reticulum, Vesicle, Aryl Hydrocarbon Receptor Nuclear Translocator, Cell Biology, Golgi apparatus, COP-Coated Vesicles, Neoplasm Proteins, Transport protein, Cell biology, Protein Transport, symbols, Molecular Medicine, Collagen, Carrier Proteins |
| الوصف: | Cargo proteins exported from the endoplasmic reticulum to the Golgi apparatus are typically transported in coat protein complex II (COPII)-coated vesicles of 60–90 nm diameter. Several cargo molecules including collagens and chylomicrons form structures that are too large to be accommodated by these vesicles, but their secretion still requires COPII proteins. Here, we first review recent progress on large cargo secretions derived especially from animal models and human diseases, which indicate the importance of COPII proteins. We then discuss the recent isolation of specialized factors that modulate the process of COPII-dependent cargo formation to facilitate the exit of large-sized cargoes from the endoplasmic reticulum. Based on these findings, we propose a model that describes the importance of the GTPase cycle for secretion of oversized cargoes. Next, we summarize reports that describe the structures of COPII proteins and how these results provide insight into the mechanism of assembly of the large cargo carriers. Finally, we discuss what issues remain to be solved in the future. |
| تدمد: | 1420-9071 1420-682X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7a67d63b14818d84388b1a9aa8b903Test https://doi.org/10.1007/s00018-015-1952-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd7a67d63b14818d84388b1a9aa8b903 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14209071 1420682X |
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