Hierarchization of myogenic and adipogenic progenitors within human skeletal muscle
| العنوان: | Hierarchization of myogenic and adipogenic progenitors within human skeletal muscle |
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| المؤلفون: | Noémie Clement, Didier F. Pisani, Sabrina Sacconi, Jean-Yves Kurzenne, Magali Plaisant, Agnès Loubat, Claude A. Dechesne, Claude Desnuelle, Christian Dani |
| المساهمون: | Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Immunite anti-tumorale et chimiotactisme. Adenocarcinomes et métastases, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR50-Université Nice Sophia Antipolis (... - 2019) (UNS), CHU Nice, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA) |
| المصدر: | Stem Cells / Stem Cells (Miamisburg) Stem Cells / Stem Cells (Miamisburg), Alphamed Press, 2010, epub ahead of print. ⟨10.1002/stem.537⟩ |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Cell type, Adolescent, Cellular differentiation, Biopsy, Population, Biology, Models, Biological, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Antigens, CD, medicine, Adipocytes, Humans, Cell Lineage, Progenitor cell, education, Child, Muscle, Skeletal, [SDV.BDD]Life Sciences [q-bio]/Development Biology, 030304 developmental biology, Aged, 0303 health sciences, education.field_of_study, Muscle Cells, Cluster of differentiation, Myogenesis, Stem Cells, Skeletal muscle, Infant, Cell Differentiation, Cell Biology, Middle Aged, CD56 Antigen, Cell biology, Clone Cells, medicine.anatomical_structure, Biochemistry, Adipogenesis, Child, Preschool, Molecular Medicine, 030217 neurology & neurosurgery, Developmental Biology |
| الوصف: | Skeletal muscle cells constitute a heterogeneous population that maintains muscle integrity through a high myogenic regenerative capacity. More unexpectedly, this population is also endowed with an adipogenic potential, even in humans, and intramuscular adipocytes have been found to be present in several disorders. We tested the distribution of myogenic and adipogenic commitments in human muscle-derived cells to decipher the cellular basis of the myoadipogenic balance. Clonal analysis showed that adipogenic progenitors can be separated from myogenic progenitors and, interestingly, from myoadipogenic bipotent progenitors. These progenitors were isolated in the CD34+ population on the basis of the expression of CD56 and CD15 cell surface markers. In vivo, these different cell types have been found in the interstitial compartment of human muscle. In vitro, we show that the proliferation of bipotent myoadipogenic CD56+CD15+ progenitors gives rise to myogenic CD56+CD15− progenitors and adipogenic CD56−CD15+ progenitors. A cellular hierarchy of muscle and fat progenitors thus occurs within human muscle. These results provide cellular bases for adipogenic differentiation in human skeletal muscle, which may explain the fat development encountered in different muscle pathological situations. |
| تدمد: | 1549-4918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5b369667f2fd445b45e9a01c0e4c95Test https://pubmed.ncbi.nlm.nih.gov/20936706Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd5b369667f2fd445b45e9a01c0e4c95 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15494918 |
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