Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection
| العنوان: | Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection |
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| المؤلفون: | Yean K. Yong, Alireza Saeidi, Hong Y. Tan, Mohamed Rosmawati, Philip F. Enström, Rami Al Batran, V. Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh, Adeeba Kamarulzaman, Jayakumar Rajarajeswaran, Abdul W. Ansari, Jamuna Vadivelu, James E. Ussher, Vijayakumar Velu, Marie Larsson, Esaki M. Shankar |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 9 (2018) |
| بيانات النشر: | Frontiers Media S.A., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Adult, Male, CD3, Receptors, Antigen, T-Cell, alpha-beta, Immunology, Programmed Cell Death 1 Receptor, Mucosal associated invariant T cell, Biology, CD38, CD8-Positive T-Lymphocytes, 03 medical and health sciences, 0302 clinical medicine, Hepatitis B, Chronic, PD-1, HLA-DR, Immunology and Allergy, Humans, immune exhaustion, HBV infection, Original Research, immunosenescence, mucosal-associated invariant T cells, CTLA-4, Mucous Membrane, T-cell receptor, Middle Aged, 030104 developmental biology, Gene Expression Regulation, 030220 oncology & carcinogenesis, Immunologi, DNA, Viral, biology.protein, Female, lcsh:RC581-607, Viral load, CD8, NK Cell Lectin-Like Receptor Subfamily B |
| الوصف: | Mucosal-associated invariant T (MAIT) cells, defined as CD161(++) TCR iV alpha 7.2(+) T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chronic hepatitis B virus (HBV) infection. The peripheral CD3(+)CD161(++)TCR iV alpha 7.2(+) MAIT cells in chronic HBV-infected patients and healthy controls were phenotypically characterized based on CD57, PD-1, TIM-3, and CTLA-4, as well as HLA-DR and CD38 expression. The frequency of MAIT cells was significantly decreased among chronic HBV-infected individuals as compared to controls. Expression of CD57, PD-1, CTLA-4, as well as HLA-DR and CD38 on MAIT cells was significantly elevated in chronic HBV-infected individuals relative to controls. The percentage of T cell receptor (TCR) iVa7.2+ CD161(+) MAIT cells did not correlate with HBV viral load but inversely with HLA-DR on CD4(+) T cells and MAIT cells and with CD57 on CD8(+) T cells suggesting that decrease of MAIT cells may not be attributed to direct infection by HBV but driven by HBV-induced chronic immune activation. The percentage and expression levels of PD-1 as well as CTLA-4 on MAIT cells inversely correlated with plasma HBV-DNA levels, which may suggest either a role for MAIT cells in the control of HBV infection or the effect of HBV replication in the liver on MAIT cell phenotype. We report that decrease of TCR iV alpha 7.2(+) MAIT cells in the peripheral blood and their functions were seemingly impaired in chronic HBV-infected patients likely because of the increased expression of PD-1. Funding Agencies|Frontier Research Grant (FRG) [FG019-17AFR] |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1c58ceec7a3c02a958eb5c481c3bd0Test http://europepmc.org/articles/PMC5868455Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd1c58ceec7a3c02a958eb5c481c3bd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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