GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis
| العنوان: | GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis |
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| المؤلفون: | Khalid Al-Rasadi, Stephen L. Atkin, Amirhossein Sahebkar, Peyman Nowrouzi-Sohrabi, Mohammad Jalali, Tannaz Jamialahmadi, Reza Tabrizi, Shahla Rezaei |
| المصدر: | Canadian Journal of Gastroenterology & Hepatology Canadian Journal of Gastroenterology and Hepatology, Vol 2021 (2021) |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, RC799-869, Review Article, Gastroenterology, Glucagon-Like Peptide-1 Receptor, Non-alcoholic Fatty Liver Disease, Internal medicine, Nonalcoholic fatty liver disease, medicine, Humans, In patient, Triglycerides, Glucagon-like peptide 1 receptor, Hepatology, medicine.diagnostic_test, biology, business.industry, Confounding, General Medicine, Diseases of the digestive system. Gastroenterology, medicine.disease, Lipids, Alanine transaminase, Meta-analysis, biology.protein, Lipid profile, business, Lipoprotein |
| الوصف: | Aims. This meta-analysis of randomized placebo-controlled clinical trials assessed the effect of glucose-like peptide-1-receptor agonists (GLP-1RA) on the lipid profile and liver enzymes in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods. Randomized placebo-controlled trials investigating GLP-1RA on the lipid profile and liver enzymes in patients with NAFLD were searched in PubMed-Medline, Scopus, Web of Science, and Google Scholar databases (from inception to January 2020). A random-effects model and a generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted. Weighted random-effects meta-regression was performed on potential confounders on lipid profile and liver enzyme concentrations. Results. 12 studies were identified (12 GLP-1RA arms; 677 subjects) that showed treatment with GLP-1RA reduced alanine transaminase (ALT) concentrations (WMD = −10.14, 95%CI = [−15.84, −0.44], P < 0.001 ), gamma-glutamyl transferase (GGT) (WMD = −11.53, 95%CI = [−15.21,−7.85], P < 0.001 ), and alaline phosphatase (ALP) (WMD = −8.29, 95%CI = [−11.34, −5.24], P < 0.001 ). Aspartate aminotransferase (AST) (WMD = −2.95, 95% CI = [−7.26, 1.37], P = 0.18 ) was unchanged. GLP-1 therapy did not alter triglycerides (TC) (WMD = −7.07, 95%CI = [−17.51, 3.37], P = 0.18 ), total cholesterol (TC) (WMD = −1.17 (−5.25, 2.91), P = 0.57 ), high-density lipoprotein (HDL-C) (WMD = 0.97, 95%CI = [−1.63, 3.58], P = 0.46 ), or low-density lipoprotein (LDL-C) (WMD = −1.67, 95%CI = [−10.08, 6.74], P = 0.69 ) in comparison with controls. Conclusion. The results of this meta-analysis suggest that GLP-1RA treatment significantly reduces liver enzymes in patients with NAFLD, but the lipid profile is unaffected. |
| تدمد: | 2291-2797 2291-2789 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdb1b3cf7cc980bc925a683fe8caae5Test https://doi.org/10.1155/2021/8936865Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fcdb1b3cf7cc980bc925a683fe8caae5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22912797 22912789 |
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