Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism
| العنوان: | Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism |
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| المؤلفون: | Katia Longo, Marco Salvatore, Arturo Brunetti, Marianna Amboni, Paolo Barone, Maria Grazia Caprio, Carmine Vitale, M. T. Pellecchia, Sabina Pappatà, Dag Aarsland, Kolbjørn Brønnick, G. De Michele, Caterina Vicidomini, Gabriella Santangelo, Roberto Erro |
| المساهمون: | Pappata', Sabina, Santangelo, Gabriella, Aarsland, D, Vicidomini, C, Longo, Katia, Bronnick, K, Amboni, Marianna, Erro, Roberto, Vitale, Carmine, Caprio, Mg, Pellecchia, Mt, Brunetti, Arturo, DE MICHELE, Giuseppe, Salvatore, Marco, Barone, Paolo, Pappatà, S, Longo, K, Amboni, M, Erro, R, Vitale, C, Brunetti, A, De Michele, G, Salvatore, M, Barone, P. |
| المصدر: | Neurology 10 (2011). info:cnr-pdr/source/autori:Pappata S.; Santangelo G.; Aarsland D.; Vicidomini C.; Longo K.; Bronnick K.; Amboni M.; Erro R.; Vitale C.; Caprio M. G.; Pellecchia M. T.; Brunetti A.; De Michele G.; Salvatore M.; Barone P./titolo:Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism/doi:/rivista:Neurology/anno:2011/pagina_da:/pagina_a:/intervallo_pagine:/volume:10 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Striatum, Neuropsychological Tests, Statistical parametric mapping, computer.software_genre, hypometabolism, Text mining, Fluorodeoxyglucose F18, Voxel, Internal medicine, mental disorders, drug-naive, medicine, Humans, Dementia, Stage (cooking), Cognitive impairment, NEUROLOGY, Mild cognitive, Aged, Cerebral Cortex, Analysis of Variance, Brain Mapping, Chi-Square Distribution, business.industry, Mild Cognitive Impairment, Parkinson's Disease, Parkinson Disease, Middle Aged, medicine.disease, nervous system diseases, Drug-naïve, Case-Control Studies, Positron-Emission Tomography, Cardiology, Female, Neurology (clinical), Cognition Disorders, business, computer, Follow-Up Studies, medicine.drug |
| الوصف: | OBJECTIVE: To characterize brain metabolic changes associated with mild cognitive impairment (MCI) in drug-naive patients with Parkinson disease (PD) using (18)F-fluorodeoxyglucose (FDG) and PET (FDG-PET). METHODS: This cross-sectional study included newly diagnosed patients with PD with MCI in single or multiple domain (PD-MCI; n =12) and without MCI (PD-nMCI; n =12), and healthy controls (n =12). The groups were matched for age. Moreover, the patient groups were matched for motor disability. All subjects underwent a FDG-PET study. Cerebral regional relative metabolic maps were compared in PD-MCI, PD-nMCI, and controls using regions of interest analysis (ROIs) and voxel-based analysis with statistical parametric mapping. RESULTS: ROIs and voxel-based analyses revealed significant relative hypometabolism in the prefrontal, superior/inferior parietal, and associative occipital cortices as well as in the striatum in patients with PD-MCI relative to controls (p < 0.05) and to a lesser extent in patients with PD-nMCI. In contrast, patients with PD-nMCI did not show significant metabolic changes as compared to controls. CONCLUSION: MCI in patients with PD is associated with cortical hypometabolism since the earliest stage, independent of therapy or motor disability. The early involvement of posterior cortical region, a pattern shared by advanced stages of PD-MCI and PD with dementia, could represent an early marker of dementia. The relevance of this pattern in predicting prodromal dementia has to be evaluated in longitudinal studies. |
| تدمد: | 1526-632X 0028-3878 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9a06090799b5b5cf855e5a7d38f104Test https://doi.org/10.1212/wnl.0b013e3182315259Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....fc9a06090799b5b5cf855e5a7d38f104 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
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