Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies
| العنوان: | Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies |
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| المؤلفون: | Sebastian M. Schmid, Martin Heni, Benjamin Assad Jaghutriz, Fausto Machicao, Róbert János Bánhegyi, Adam G. Tabak, Ellen Fehlert, Andreas Peter, Hans-Ulrich Häring, Robert Wagner, Harald Staiger, Andreas Fritsche, Louise Fritsche |
| المصدر: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) Sci. Rep. 7:15486 (2017) |
| بيانات النشر: | Nature Publishing Group UK, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Glucose, Male, lcsh:Medicine, Type 2 diabetes, Weight Gain, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Longitudinal Studies, Prospective Studies, lcsh:Science, Multidisciplinary, Fasting, Middle Aged, Female, medicine.symptom, Glycolysis, Adult, medicine.medical_specialty, Genotype, Energy metabolism, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, 030209 endocrinology & metabolism, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Internal medicine, Diabetes mellitus, medicine, Humans, Genetic Predisposition to Disease, Obesity, Triglycerides, Triglyceride, business.industry, lcsh:R, Weight change, Body Weight, nutritional and metabolic diseases, medicine.disease, Lipid Metabolism, 030104 developmental biology, Endocrinology, chemistry, lcsh:Q, business, Energy Metabolism, Body mass index, Weight gain |
| الوصف: | Variation in FTO is the most important common genetic determinant of body weight. Altered energy metabolism could underlie this association. We hypothesized that higher circulating glucose or triglycerides can amplify the FTO impact on BMI. In 2671 subjects of the TUEF study, we investigated the interaction effect of fasting glucose and triglyceride levels with rs9939609 in FTO on BMI. We analysed the same interaction effect by longitudinally utilizing mixed effect models in the prospective Whitehall II study. In TUEF, we detected an interaction effect between fasting glucose and fasting triglycerides with rs9939609 on BMI (p = 0.0005 and p = 5 × 10(-7), respectively). The effect size of one risk allele was 1.4 ± 0.3 vs. 2.2 ± 0.44 kg/m² in persons with fasting glucose levels below and above the median, respectively. Fasting triglycerides above the median increased the per-allele effect from 1.4 ± 0.3 to 1.7 ± 0.4 kg/m(2). In the Whitehall II study, body weight increased by 2.96 ± 6.5 kg during a follow-up of 13.5 ± 4.6 yrs. Baseline fasting glucose and rs9939609 interacted on weight change (p = 0.009). Higher fasting glucose levels may amplify obesity-risk in FTO carriers and lead to an exaggerated weight gain over time. Since weight gain perpetuates metabolic alterations, this interplay may trigger a vicious circle that leads to obesity and diabetes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc92d1b64cde1e43181eec73e7db5f5eTest http://europepmc.org/articles/PMC5686126Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fc92d1b64cde1e43181eec73e7db5f5e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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