Selenium Regulates Gene Expression of Selenoprotein W in Chicken Skeletal Muscle System
| العنوان: | Selenium Regulates Gene Expression of Selenoprotein W in Chicken Skeletal Muscle System |
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| المؤلفون: | Qiong Wu, Ziwei Zhang, Shu Li, Jin-Long Li, Haidong Yao, Shiwen Xu, Hongfeng Ruan |
| المصدر: | Biological Trace Element Research. 145:59-65 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Gene Expression, chemistry.chemical_element, Biology, Biochemistry, Avian Proteins, Myoblasts, Inorganic Chemistry, Random Allocation, Sodium Selenite, Internal medicine, Gene expression, medicine, Animals, Myocyte, RNA, Messenger, Muscle, Skeletal, Cells, Cultured, Messenger RNA, Reverse Transcriptase Polymerase Chain Reaction, Biochemistry (medical), RNA, Skeletal muscle, General Medicine, Selenoprotein W, Metabolism, Endocrinology, medicine.anatomical_structure, Animals, Newborn, chemistry, Dietary Supplements, Chickens, Selenium |
| الوصف: | Selenoprotein W (SelW) is abundantly expressed in skeletal muscles of mammals and necessary for the metabolism of skeletal muscles. However, its expression pattern in skeletal muscle system of birds is still uncovered. Herein, to investigate the distribution of SelW mRNA in chicken skeletal muscle system and its response to different selenium (Se) status, 1-day-old chickens were exposed to various concentrations of Se as sodium selenite in the feed for 35 days. In addition, myoblasts were treated with different concentrations of Se in the medium for 72 h. Then the levels of SelW mRNA in skeletal muscles (wing muscle, pectoral muscle, thigh muscle) and myoblasts were determined on days 1, 15, 25, and 35 and at 0, 24, 48, and 72 h, respectively. The results showed that SelW was detected in all these muscle components and it increased both along with the growth of organism and the differentiation process of myoblasts. The thigh muscle is more responsive to Se intake than the other two skeletal muscle tissues while the optimal Se supplementation for SelW mRNA expression in chicken myoblasts was 10(-7) M. In summary, Se plays important roles in the development of chicken skeletal muscles. To effect optimal SelW gene expression, Se must be provided in the diet and the media in adequate amounts and neither at excessive nor deficient levels. |
| تدمد: | 1559-0720 0163-4984 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc62b2158ab638c0514c25973791b466Test https://doi.org/10.1007/s12011-011-9166-yTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fc62b2158ab638c0514c25973791b466 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590720 01634984 |
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