Underreported Threat of Multidrug-Resistant Tuberculosis in Africa
| العنوان: | Underreported Threat of Multidrug-Resistant Tuberculosis in Africa |
|---|---|
| المؤلفون: | Bennett Nemser, Yanis Ben Amor, Alyssa Sankin, Neil W. Schluger, Angad Singh |
| المصدر: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 14, Iss 9, Pp 1345-1352 (2008) |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Microbiology (medical), Drug, Tuberculosis, Adolescent, Epidemiology, media_common.quotation_subject, 030231 tropical medicine, Antitubercular Agents, Human immunodeficiency virus (HIV), lcsh:Medicine, Developing country, HIV Infections, Drug resistance, Pharmacology, medicine.disease_cause, lcsh:Infectious and parasitic diseases, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, multidrug resistance, Drug Resistance, Multiple, Bacterial, Environmental health, Tuberculosis, Multidrug-Resistant, Prevalence, Humans, Medicine, lcsh:RC109-216, 030212 general & internal medicine, media_common, biology, business.industry, Incidence, Incidence (epidemiology), lcsh:R, 1. No poverty, Middle Aged, medicine.disease, biology.organism_classification, 3. Good health, Multiple drug resistance, Infectious Diseases, Africa, Perspective, Regression Analysis, business |
| الوصف: | Identification of population-based factors should influence regional and national policy. Multidrug-resistant tuberculosis (MDR TB) in Africa may be more prevalent than previously appreciated. Factors leading to development of drug resistance need to be understood to develop appropriate control strategies for national programs. We gathered estimates of MDR TB rates for 39 of 46 countries in Africa. The relationship between MDR TB rates and independent factors was analyzed by using correlation and linear regression models. Our findings indicate that drug resistance surveys in Africa are critically needed. MDR TB rates must be assessed in countries without these surveys. In countries that have conducted a drug resistance survey, a new survey will determine evolution of drug resistance rates. We found no correlation between high MDR rates and TB incidence, HIV/TB co-infection rates, or year of introduction of rifampin. Results show that the retreatment failure rate was the most predictive indicator for MDR TB. Current category II drug regimens may increase MDR TB. |
| تدمد: | 1080-6059 1080-6040 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc50b4a7fd2411b8e127d338ba35df96Test https://doi.org/10.3201/eid1409.061524Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fc50b4a7fd2411b8e127d338ba35df96 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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