Hypoglycemia Unawareness in Older Compared With Middle-Aged Patients With Type 2 Diabetes
| العنوان: | Hypoglycemia Unawareness in Older Compared With Middle-Aged Patients With Type 2 Diabetes |
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| المؤلفون: | Jan Phillip Bremer, Bernd Schultes, Kamila Jauch-Chara, Sebastian M. Schmid, Manfred Hallschmid |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Research design, medicine.medical_specialty, Pediatrics, Epinephrine, Hydrocortisone, Endocrinology, Diabetes and Metabolism, Blood sugar, Type 2 diabetes, Hypoglycemia, Norepinephrine, Cognition, Adrenocorticotropic Hormone, Internal medicine, Diabetes mellitus, Reaction Time, Internal Medicine, medicine, Humans, Pathophysiology/Complications, Original Research, Aged, Aged, 80 and over, Advanced and Specialized Nursing, business.industry, Awareness, Middle Aged, Glucagon, medicine.disease, Middle age, Endocrinology, Diabetes Mellitus, Type 2, Growth Hormone, Sensory Thresholds, Female, Cognition Disorders, business, medicine.drug |
| الوصف: | OBJECTIVE Older patients with type 2 diabetes are at a particularly high risk for severe hypoglycemic episodes, and experimental studies in healthy subjects hint at a reduced awareness of hypoglycemia in aged humans. However, subjective responses to hypoglycemia have rarely been assessed in older type 2 diabetic patients. RESEARCH DESIGN AND METHODS We tested hormonal, subjective, and cognitive responses (reaction time) to 30-min steady-state hypoglycemia at a level of 2.8 mmol/l in 13 older (≥65 years) and 13 middle-aged (39–64 years) type 2 diabetic patients. RESULTS Hormonal counterregulatory responses to hypoglycemia did not differ between older and middle-aged patients. In contrast, middle-aged patients showed a pronounced increase in autonomic and neuroglycopenic symptom scores at the end of the hypoglycemic plateau that was not observed in older patients (both P < 0.01). Also, seven middle-aged patients, but only one older participant, correctly estimated their blood glucose concentration to be CONCLUSIONS Our data indicate marked subjective unawareness of hypoglycemia in older type 2 diabetic patients that does not depend on altered neuroendocrine counterregulation and may contribute to the increased probability of severe hypoglycemia frequently reported in these patients. The joint occurrence of hypoglycemia unawareness and deteriorated cognitive function is a critical factor to be carefully considered in the treatment of older patients. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc39d52098cb63edca3a0dbf5f4b3002Test https://doi.org/10.2337/dc09-0114Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fc39d52098cb63edca3a0dbf5f4b3002 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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