Endometriosis Is Associated with Functional Polymorphism in the Promoter of Heme Oxygenase 1 (HMOX1) Gene
| العنوان: | Endometriosis Is Associated with Functional Polymorphism in the Promoter of Heme Oxygenase 1 (HMOX1) Gene |
|---|---|
| المؤلفون: | Jacek Malejczyk, Marta Soszyńska, Aneta Ścieżyńska, Paweł Kamiński, Łukasz Milewski, Rafał Płoski, Piotr I. Roszkowski, Paweł Włodarski, Ewa Barcz, Joanna Ponińska |
| المصدر: | Cells, Vol 10, Iss 695, p 695 (2021) Cells; Volume 10; Issue 3; Pages: 695 Cells |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, endometriosis, medicine.medical_specialty, HMOX1, Endometriosis, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Gene Frequency, Polymorphism (computer science), Internal medicine, medicine, SNP, Humans, Genetic Predisposition to Disease, Promoter Regions, Genetic, lcsh:QH301-705.5, Genetic Association Studies, 030219 obstetrics & reproductive medicine, Haplotype, General Medicine, inflammatory response, Middle Aged, single-nucleotide polymorphism, medicine.disease, Heme oxygenase, 030104 developmental biology, Endocrinology, Haplotypes, lcsh:Biology (General), Case-Control Studies, HMOX1 Gene, Female, heme oxygenase 1, Heme Oxygenase-1 |
| الوصف: | Endometriosis is a common gynecological disorder characterized by the ectopic growth of endometrial-like tissue outside the uterine cavity. Etiopathogenesis of endometriosis is poorly understood; it is plausible, however, that the disease may be associated with oxidative stress related to local heme and iron metabolism. Therefore, the aim of the study was to reveal a possible association of endometriosis with a stress-inducible heme oxygenase 1 (HMOX1). For this purpose, 228 patients with clinically confirmed endometriosis and 415 control parous women from general Polish population were examined for functional –413A>T (rs2071746) single-nucleotide polymorphism (SNP) and (GT)n dinucleotide repeat length polymorphism in the promoter of HMOX1 gene. In addition, –413A>T SNP was assessed by the specific TaqMan® SNP Genotyping Assay, and (GT)n polymorphism was determined by PCR product size analysis. We found that endometriosis is associated with an increased frequency of −413A(GT)31,32 haplotype (OR (95%CI) = 1.27 (1.01–1.60), p = 0.0381) and −413A(GT)31,32 homozygous genotype [OR (95%CI) = 1.51 (1.06–2.17), p = 0.0238]. These data suggest that endometriosis is associated with functional polymorphism of HMOX1 gene, and this gene may play a part in the pathogenesis of this disorder. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbad21b96e35cbe6ac746fbc0155fe4eTest https://www.mdpi.com/2073-4409/10/3/695Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fbad21b96e35cbe6ac746fbc0155fe4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
|---|