Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors
| العنوان: | Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors |
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| المؤلفون: | Cara B. Borja, Justin N. Siemian, Sarah Sarsfield, Miguel A. Arenivar, Yeka Aponte, Charity N. Russell |
| المصدر: | Cell Reports, Vol 36, Iss 8, Pp 109615-(2021) Cell reports |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | consummatory behaviors, Lateral hypothalamus, QH301-705.5, Population, ventral tegmental area, Mice, Transgenic, Optogenetics, Biology, neuronal circuits, Article, General Biochemistry, Genetics and Molecular Biology, Reward, medicine, Animals, Learning, Biology (General), education, leptin receptor, Appetitive Behavior, education.field_of_study, Leptin receptor, Behavior, Animal, Classical conditioning, Chemogenetics, lateral hypothalamus, Ventral tegmental area, appetitive behaviors, medicine.anatomical_structure, nervous system, Hypothalamic Area, Lateral, GABAergic, Neuroscience |
| الوصف: | SUMMARY Assigning behavioral roles to genetically defined neurons within the lateral hypothalamus (LH) is an ongoing challenge. We demonstrate that a subpopulation of LH GABAergic neurons expressing leptin receptors (LHLEPR) specifically drives appetitive behaviors in mice. Ablation of LH GABAergic neurons (LHVGAT) decreases weight gain and food intake, whereas LHLEPR ablation does not. Appetitive learning in a Pavlovian conditioning paradigm is delayed in LHVGAT-ablated mice but prevented entirely in LHLEPR-ablated mice. Both LHVGAT and LHLEPR neurons bidirectionally modulate reward-related behaviors, but only LHVGAT neurons affect feeding. In the Pavlovian paradigm, only LHLEPR activity discriminates between conditioned cues. Optogenetic activation or inhibition of either population in this task disrupts discrimination. However, manipulations of LHLEPR→VTA projections evoke divergent effects on responding. Unlike food-oriented learning, chemogenetic inhibition of LHLEPR neurons does not alter cocaine-conditioned place preference but attenuates cocaine sensitization. Thus, LHLEPR neurons may specifically regulate appetitive behaviors toward non-drug reinforcers. Graphical Abstract In brief Siemian et al. investigate the functional contributions of leptin receptor-expressing lateral hypothalamic (LHLEPR) neurons to the broader population of GABAergic LH (LHVGAT) neurons in mice. They show that LHLEPR neurons specifically mediate appetitive behaviors, whereas LHVGAT neurons affect appetitive, consummatory, and displacement behaviors. |
| اللغة: | English |
| تدمد: | 2211-1247 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb83743c5692f017dcffb7aa98307232Test http://www.sciencedirect.com/science/article/pii/S2211124721010536Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fb83743c5692f017dcffb7aa98307232 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22111247 |
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