Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan
| العنوان: | Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan |
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| المؤلفون: | Naoto Shimeno, Yasutoshi Sakamoto, Tetsuo Nemoto, Mizuo Ando, Koichi Kano, Shinichiro Hori, Kenichi Takemura, Tamotsu Matsuhashi, Hirohito Umeno, Ryuichi Hayashi, Atsushi Ochiai, Akiko Takahashi, Akihiro Shiotani, Manabu Muto, Takakuni Kato, Yasuaki Nagami, Shigetaka Yoshinaga, Makoto Abe, Tetsuji Yokoyama, Toshiro Iizuka, Kenro Kawada, Kenichi Goda, Yukinori Asada, Yuichi Shimizu, Hidenobu Watanabe, Akihito Arai, Kenji Okami, Satoshi Fujii, Shuji Terai, Tadakazu Shimoda, Chikatoshi Katada, Noboru Hanaoka, Masaaki Ichinoe, Tomonori Yano, Hiroki Mitani, Yoichiro Ono, Akihito Watanabe, Tomoyuki Kamijo, Ichiro Tateya, Masahiro Fujita |
| المصدر: | Cancer Medicine Cancer Medicine, Vol 10, Iss 12, Pp 3848-3861 (2021) |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Cancer Research, larynx preservation, pharyngeal cancer, transoral surgery, Severity of Illness Index, 0302 clinical medicine, Postoperative Complications, Japan, RC254-282, Original Research, Aged, 80 and over, Incidence (epidemiology), Incidence, superficial cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Neoplasms, Second Primary, Middle Aged, Tumor Burden, Survival Rate, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Female, Larynx, Carcinoma in Situ, Adult, Natural Orifice Endoscopic Surgery, medicine.medical_specialty, Operative Time, Disease-Free Survival, 03 medical and health sciences, medicine, Humans, Radiology, Nuclear Medicine and imaging, Adverse effect, Survival rate, Pathological, Aged, Retrospective Studies, business.industry, Squamous Cell Carcinoma of Head and Neck, Head and neck cancer, Clinical Cancer Research, medicine.disease, Head and neck squamous-cell carcinoma, Surgery, Clinical trial, 030104 developmental biology, head and neck cancer, Transoral surgery, business, Organ Sparing Treatments |
| الوصف: | Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real‐world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1–75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2–357). Adverse events occurred in 12.7%. Life‐threatening complications occurred in 0.5%, but there were no treatment‐related deaths. During a median follow‐up period of 46.1 months (range 1–113), the 3‐year overall survival rate, relapse‐free survival rate, cause‐specific survival rate, and larynx‐preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment. Clinical trials registry number: UMIN000008276. This is the first report on nationwide survival data and pathological criteria of superficial head and neck cancer. Transoral surgery for superficial head and neck cancer was safe and offered highly curative minimally invasive treatment preserving organs and their function. Subepithelial invasion was clinically useful predictor of recurrence after transoral surgery. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-7634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4ab94caa88f3ad1d897d88c11a78d1Test http://europepmc.org/articles/PMC8209601Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fb4ab94caa88f3ad1d897d88c11a78d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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