Metabolomics and complementary techniques to investigate the plant phytochemical cosmos
| العنوان: | Metabolomics and complementary techniques to investigate the plant phytochemical cosmos |
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| المؤلفون: | Hiroshi Tsugawa, Amit Rai, Kazuki Saito, Ryo Nakabayashi |
| المصدر: | Natural Product Reports. 38:1729-1759 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Informatics, Metabolite, Phytochemicals, Organic Chemistry, Genomics, Computational biology, Plants, Biology, Biochemistry, Mass Spectrometry, Machine Learning, chemistry.chemical_compound, Molecular network, Metabolomics, chemistry, Phytochemical, Artificial Intelligence, Cheminformatics, Multigene Family, Drug Discovery, Metabolome, Identification (biology), Genome, Plant |
| الوصف: | Covering: up to 2021Plants and their associated microbial communities are known to produce millions of metabolites, a majority of which are still not characterized and are speculated to possess novel bioactive properties. In addition to their role in plant physiology, these metabolites are also relevant as existing and next-generation medicine candidates. Elucidation of the plant metabolite diversity is thus valuable for the successful exploitation of natural resources for humankind. Herein, we present a comprehensive review on recent metabolomics approaches to illuminate molecular networks in plants, including chemical isolation and enzymatic production as well as the modern metabolomics approaches such as stable isotope labeling, ultrahigh-resolution mass spectrometry, metabolome imaging (spatial metabolomics), single-cell analysis, cheminformatics, and computational mass spectrometry. Mass spectrometry-based strategies to characterize plant metabolomes through metabolite identification and annotation are described in detail. We also highlight the use of phytochemical genomics to mine genes associated with specialized metabolites' biosynthesis. Understanding the metabolic diversity through biotechnological advances is fundamental to elucidate the functions of the plant-derived specialized metabolome. |
| تدمد: | 1460-4752 0265-0568 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3b7f9b17aca33be1f589decdd08fbaTest https://doi.org/10.1039/d1np00014dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fb3b7f9b17aca33be1f589decdd08fba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14604752 02650568 |
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