Prognostic Factors for Survival of MEN1 Patients with Duodenopancreatic Tumors Metastatic to the Liver: Results from the DMSG
| العنوان: | Prognostic Factors for Survival of MEN1 Patients with Duodenopancreatic Tumors Metastatic to the Liver: Results from the DMSG |
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| المؤلفون: | Madeleine L. Drent, Carolina R. C. Pieterman, Sjoerd Nell, Gerlof D. Valk, Elfi B. Conemans, Peter H. Bisschop, Olaf M. Dekkers, Wouter W. de Herder, Menno R. Vriens, Ad R. M. M. Hermus, Bas Havekes, Anouk N A van der Horst-Schrivers |
| المساهمون: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Clinical Neuropsychology, IBBA, Interne Geneeskunde, MUMC+: MA Endocrinologie (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - R1 - Metabolic Syndrome, Internal Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, AMS - Amsterdam Movement Sciences, Endocrinology, Internal medicine, AGEM - Endocrinology, metabolism and nutrition |
| المصدر: | Endocrine practice, 23(6), 641-648. AMER ASSOC CLINICAL ENDOCRINOLOGISTS Endocrine Practice, 23(6), 641-648 Endocrine Practice, 23, 6, pp. 641-648 Endocrine Practice, 23(6), 641-648. American Association of Clinical Endocrinologists Endocrine Practice, 23, 641-648 Endocrine Practice, 23(6), 641-648. American Association of Clinical Endocrinology Conemans, E B, Nell, S, Pieterman, C R C, de Herder, W W, Dekkers, O M, Hermus, A R, van der Horst-Schrivers, A N, Bisschop, P H, Havekes, B, Drent, M L, Vriens, M R & Valk, G D 2017, ' PROGNOSTIC FACTORS FOR SURVIVAL OF MEN1 PATIENTS WITH DUODENOPANCREATIC TUMORS METASTATIC TO THE LIVER : RESULTS FROM THE DMSG ', Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, vol. 23, no. 6, pp. 641-648 . https://doi.org/10.4158/EP161639.ORTest Endocrine practice, 23(6), 641-648. American Association of Clinical Endocrinology Conemans, E B, Nell, S, Pieterman, C R C, de Herder, W W, Dekkers, O M, Hermus, A R, van der Horst-Schrivers, A N, Bisschop, P H, Havekes, B, Drent, M L, Vriens, M R & Valk, G D 2017, ' PROGNOSTIC FACTORS FOR SURVIVAL OF MEN1 PATIENTS WITH DUODENOPANCREATIC TUMORS METASTATIC TO THE LIVER : RESULTS FROM THE DMSG ', Endocrine Practice, vol. 23, no. 6, pp. 641-648 . https://doi.org/10.4158/EP161639.ORTest Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 23(6), 641-648. American Association of Clinical Endocrinology |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Databases, Factual, Endocrinology, Diabetes and Metabolism, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Neuroendocrine tumors, GUIDELINES, Gastroenterology, 0302 clinical medicine, Endocrinology, Duodenal Neoplasms, Cause of Death, Multiple endocrine neoplasia, Cause of death, Netherlands, ENDOCRINE NEOPLASIA TYPE-1, education.field_of_study, Liver Neoplasms, General Medicine, Middle Aged, Prognosis, Survival Rate, Neuroendocrine Tumors, 030220 oncology & carcinogenesis, Female, Cohort study, Adult, medicine.medical_specialty, Population, DES-TUMEURS-ENDOCRINES, 030209 endocrinology & metabolism, 03 medical and health sciences, Databases, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Journal Article, Multiple Endocrine Neoplasia Type 1, MANAGEMENT, Humans, MEN1, education, Survival rate, Survival analysis, Factual, Aged, business.industry, GTE, medicine.disease, Surgery, Pancreatic Neoplasms, business, NEUROENDOCRINE TUMORS |
| الوصف: | Item does not contain fulltext OBJECTIVE: Duodenopancreatic neuroendocrine tumors (DP-NETs) develop in a majority of patients with multiple endocrine neoplasia type 1 (MEN1) and are the leading cause of death. Overall survival (OS) and prognostic factors for patients with liver metastases from DP-NETs are not known. METHODS: This was a cohort study using the Dutch National MEN1 database, which includes >90% of the Dutch MEN1 population treated between 1990 and 2014. OS was assessed with time to event analysis, and prognostic factors were evaluated. RESULTS: A total of 56% of the MEN1 patients (n = 220) were diagnosed with a DP-NET, of who 34 (15%) developed DP-NET liver metastases. Median age at liver metastases diagnosis was 53 years (range 31-74). Of those patients, 16 patients (47%) had died after a median follow-up of 4 years (range 0.3-12.3). OS at 2, 5, and 10 years were 91%, 65%, and 50%, respectively. A trend towards worse survival was seen in males compared to females (5-year OS 58% versus 75%, P = .07) and also in patients with multiple liver metastases compared to patients with solitary liver metastasis (59 versus 83%, P = .09). CONCLUSION: Despite the fairly indolent course of DP-NET liver metastases in MEN1 patients, half of the population was deceased after 10 years. Sex and tumor load at diagnosis of liver metastases are possible prognostic factors for worse survival. ABBREVIATIONS: DMSG = DutchMEN1 Study Group; D-NET = duodenal neuroendocrine tumor; DP-NET = duodenopancreatic neuroendocrine tumor; HPF = high-power field; Ki67 LI = Ki67 labeling index; MEN1 = multiple endocrine neoplasia type 1; NET = neuroendocrine tumor; OS = overall survival; P-NET = pancreatic neuroendocrine tumor; PPI = proton pump inhibitor; ULN = upper limit of normal; WHO = World Health Organization. 01 juni 2017 |
| اللغة: | English |
| تدمد: | 1530-891X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb35db016ef655581c9b9adf67486897Test https://research.rug.nl/en/publications/cec64e37-fcf3-4f32-bece-2cc3b4f6aa65Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....fb35db016ef655581c9b9adf67486897 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1530891X |
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