Quantifying the Economic Impact of Delayed Multiple-Inhaler Triple Therapy Initiation in Patients with COPD: A Retrospective Cohort Study of Linked Electronic Medical Record and Hospital Administrative Data in England
| العنوان: | Quantifying the Economic Impact of Delayed Multiple-Inhaler Triple Therapy Initiation in Patients with COPD: A Retrospective Cohort Study of Linked Electronic Medical Record and Hospital Administrative Data in England |
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| المؤلفون: | G. Anley, Robert Wood, Afisi S. Ismaila, Leah B Sansbury, Yein Nam |
| المصدر: | International Journal of Chronic Obstructive Pulmonary Disease |
| بيانات النشر: | Dove, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Exacerbation, Pulmonary disease, Muscarinic Antagonists, International Journal of Chronic Obstructive Pulmonary Disease, chronic obstructive pulmonary disease, Cohort Studies, Pulmonary Disease, Chronic Obstructive, exacerbation, Internal medicine, multiple-inhaler triple therapy, Administration, Inhalation, medicine, Electronic Health Records, Humans, In patient, Longitudinal Studies, Longitudinal cohort, Adrenergic beta-2 Receptor Agonists, Original Research, Aged, Retrospective Studies, COPD, business.industry, Inhaler, Nebulizers and Vaporizers, Electronic medical record, healthcare utilization, Retrospective cohort study, General Medicine, medicine.disease, Hospitals, Bronchodilator Agents, England, triple therapy, business |
| الوصف: | Leah B Sansbury,1 Robert P Wood,2 Glenn A Anley,3 Yein Nam,2 Afisi S Ismaila4,5 1Epidemiology, Value Evidence and Outcomes, GlaxoSmithKline, Research Triangle Park, NC, USA; 2Observational Research, Adelphi Real World, Bollington, UK; 3UK Health Outcomes, GlaxoSmithKline, Uxbridge, UK; 4Value Evidence and Outcomes, GlaxoSmithKline, Collegeville, PA, USA; 5Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, CanadaCorrespondence: Afisi S IsmailaValue Evidence and Outcomes, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, 19426-0989, USATel +1 919 315 8229Email afisi.s.ismaila@gsk.comPurpose: To assess if early multiple-inhaler triple therapy (MITT) initiation in patients with chronic obstructive pulmonary disease (COPD) reduces subsequent healthcare resource utilization (HCRU), direct medical costs, and acute exacerbations of COPD (AECOPDs).Patients and Methods: This retrospective, longitudinal cohort study used electronic health records and linked hospital administrative data in England. COPD patients with an AECOPD between July 2012 and May 2016 (index), and who subsequently started MITT within 180 days were eligible. Patients with an AECOPD 6 months prior to index were excluded. HCRU, direct healthcare costs, and AECOPDs were assessed in the following 24-month period for early (⤠30 days) and delayed (31â 180 days) MITT initiators.Results: A total of 934 patients were included in the analysis and categorized as early (n=367, 39%) or delayed (n=567, 61%) MITT initiators. Mean patient age was 68.5 years and 53.2% were male. A significantly higher proportion of delayed MITT initiators required ⥠1 outpatient appointment (all-cause) compared with early MITT initiators (87% vs 79%; p=0.0016). A significantly higher proportion of delayed MITT initiators required ⥠1 COPDârelated inpatient stay versus early MITT initiators (47% vs 40%; p=0.0262). Over the 24-month follow-up, mean all-cause and COPD-related total healthcare costs were significantly higher in delayed MITT initiators compared with early MITT initiators (allâcause: £ 11,348 vs £ 8126; p=0.0011; COPD-related: £ 7307 vs £ 4535; p=0.0009).Conclusion: Delayed initiation of multiple-inhaler triple therapy was associated with higher all-cause and COPD-related costs, suggesting that earlier initiation of triple therapy in COPD patients may help reduce the economic burden on the healthcare system.Keywords: chronic obstructive pulmonary disease, England, exacerbation, healthcare utilization, multiple-inhaler triple therapy, triple therapy |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1178-2005 1176-9106 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac573e405346397038abe7673c76098Test http://europepmc.org/articles/PMC8517427Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fac573e405346397038abe7673c76098 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11782005 11769106 |
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