Association of time in range with hemoglobin A1c, glycated albumin and 1,5‐anhydro‐d‐glucitol
| العنوان: | Association of time in range with hemoglobin A1c, glycated albumin and 1,5‐anhydro‐d‐glucitol |
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| المؤلفون: | Mitsuyoshi Namba, Taku Tsunoda, Satoshi Matsutani, Tomoyuki Katsuno, Yoshiki Kusunoki, Mana Ohigashi, Kahori Washio, Toshihiro Matsuo, Hidenori Koyama, Keiko Osugi, Kosuke Konishi |
| المصدر: | Journal of Diabetes Investigation, Vol 12, Iss 6, Pp 940-949 (2021) Journal of Diabetes Investigation |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Glycation End Products, Advanced, Male, Time Factors, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030204 cardiovascular system & hematology, Gastroenterology, Impaired glucose tolerance, 0302 clinical medicine, Glycated albumin, Glycated Serum Albumin, Continuous glucose monitoring, Articles, General Medicine, Middle Aged, Clinical Science and Care, Original Article, Female, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Glycemic Control, Deoxyglucose, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Glucose Intolerance, Internal Medicine, medicine, Humans, Serum Albumin, Aged, Glucose Metabolism Disorders, Retrospective Studies, Glycemic, Glycated Hemoglobin, Type 1 diabetes, business.industry, Blood Glucose Self-Monitoring, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, medicine.disease, RC648-665, Confidence interval, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Hemoglobin A1c, Time in range, Hemoglobin, business |
| الوصف: | Aims/Introduction Hemoglobin A1c (HbA1c), glycated albumin (GA) and 1,5‐anhydro‐d‐glucitol (1,5‐AG) are used as indicators of glycemic control, whereas continuous glucose monitoring (CGM) is used to assess daily glucose profiles. The aim of this study was to investigate the relationships between CGM metrics, such as time in range (TIR), and glycemic control indicators. Materials and Methods We carried out retrospective CGM and blood tests on 189 outpatients with impaired glucose tolerance (n = 22), type 1 diabetes mellitus (n = 67) or type 2 diabetes mellitus (n = 100). Results In type 1 diabetes mellitus and type 2 diabetes mellitus patients, HbA1c and GA were negatively correlated with TIR, whereas 1,5‐AG was positively correlated with TIR. In type 1 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1,5‐AG of 6.9% (95% confidence interval [CI] 6.5–7.2%), 20.3% (95% CI 19.0–21.7%) and 6.0 µg/mL (95% CI 5.1–6.9 µg/mL), respectively. In type 2 diabetes mellitus patients, a TIR of 70% corresponded to HbA1c, GA and 1,5‐AG of 7.1% (95% CI 7.0–7.3%), 19.3% (95% CI 18.7–19.9%) and 10.0 µg/mL (95% CI 9.0–11.0 µg/mL), respectively. TIR values corresponding to HbA1c levels of 7.0% were 56.1% (95% CI 52.3–59.8%) and 74.2% (95% CI 71.3–77.2%) in type 1 diabetes mellitus and type 2 diabetes mellitus patients, respectively. Conclusions The results of this study showed that the estimated HbA1c corresponding to a TIR of 70% was approximately 7.0% for both type 1 diabetes mellitus and type 2 diabetes mellitus patients, and that the estimated 1,5‐AG calculated from the TIR of 70% might be different between type 1 diabetes mellitus and type 2 diabetes mellitus patients. Hemoglobin A1c was the most useful explanatory factor for mean sensor glucose levels. Glycated albumin was the most useful explanatory factor for glycemic variability and time in range. |
| اللغة: | English |
| تدمد: | 2040-1116 2040-1124 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa45063b321f25b0e0ca8df59292d0e2Test https://doaj.org/article/42e2910c951147b39295cfca44d7ff10Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fa45063b321f25b0e0ca8df59292d0e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401116 20401124 |
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