Combined Effects of Quercetin and Atenolol in Reducing Isoproterenol-Induced Cardiotoxicity in Rats: Possible Mediation Through Scavenging Free Radicals
| العنوان: | Combined Effects of Quercetin and Atenolol in Reducing Isoproterenol-Induced Cardiotoxicity in Rats: Possible Mediation Through Scavenging Free Radicals |
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| المؤلفون: | Anand Kar, Tushar Banerjee, Sunanda Panda, Neha Sharma |
| المصدر: | Cardiovascular Toxicology. 12:235-242 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Cardiotonic Agents, Injections, Subcutaneous, Administration, Oral, Pharmacology, Toxicology, Lipid peroxidation, Necrosis, chemistry.chemical_compound, Oral administration, Lactate dehydrogenase, medicine, Animals, Rats, Wistar, Molecular Biology, Antihypertensive Agents, chemistry.chemical_classification, Myocardium, Glutathione peroxidase, Isoproterenol, Heart, Free Radical Scavengers, Glutathione, Adrenergic beta-Agonists, Atenolol, Malondialdehyde, Enzymes, Rats, Disease Models, Animal, chemistry, Drug Therapy, Combination, Quercetin, Cardiology and Cardiovascular Medicine, medicine.drug |
| الوصف: | In this investigation, combined effects of quercetin and atenolol in the regulation of isoproterenol (ISO)-induced cardiotoxicity have been evaluated in rats. While ISO administration increased the levels of serum creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and glutamate pyruvate transaminase (SGPT) as well as cardiac malondialdehyde (MDA); it reduced the activities of superoxide dismutase, catalase, glutathione peroxidase and the level of reduced glutathione. ISO-induced rats also exhibited ST-segment elevation and tachycardia. Oral administration of atenolol (6 mg/kg) and quercetin (5 mg/kg), along with ISO (5 mg/kg, subcutaneously) every day for 10 days markedly reduced the serum CK-MB, LDH and SGPT levels. Concomitantly the test drugs improved the status of antioxidative enzymes, decreased the cardiac MDA and nearly normalized the electrocardiogram. Electron paramagnetic resonance study also revealed a decrease in 5,5'-dimethyl-1-pyroline-N-oxide-hydroxyl radicals signal intensity when atenolol and quercetin were administered together to ISO-treated rats. In conclusion, the combined treatment of atenolol and quercetin appears to produce a better cardioprotective effect in ISO-induced animals as compared to their individual treatments, and possibly the beneficial actions are associated with the free radical scavenging action of quercetin. |
| تدمد: | 1559-0259 1530-7905 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f947f523829e0aa36e44e8239b24a554Test https://doi.org/10.1007/s12012-012-9161-3Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f947f523829e0aa36e44e8239b24a554 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590259 15307905 |
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