Emergence of methicillin resistance predates the clinical use of antibiotics
| العنوان: | Emergence of methicillin resistance predates the clinical use of antibiotics |
|---|---|
| المؤلفون: | Jesper Larsen, Claire L. Raisen, Xiaoliang Ba, Nicholas J. Sadgrove, Guillermo F. Padilla-González, Monique S. J. Simmonds, Igor Loncaric, Heidrun Kerschner, Petra Apfalter, Rainer Hartl, Ariane Deplano, Stien Vandendriessche, Barbora Černá Bolfíková, Pavel Hulva, Maiken C. Arendrup, Rasmus K. Hare, Céline Barnadas, Marc Stegger, Raphael N. Sieber, Robert L. Skov, Andreas Petersen, Øystein Angen, Sophie L. Rasmussen, Carmen Espinosa-Gongora, Frank M. Aarestrup, Laura J. Lindholm, Suvi M. Nykäsenoja, Frederic Laurent, Karsten Becker, Birgit Walther, Corinna Kehrenberg, Christiane Cuny, Franziska Layer, Guido Werner, Wolfgang Witte, Ivonne Stamm, Paolo Moroni, Hannah J. Jørgensen, Hermínia de Lencastre, Emilia Cercenado, Fernando García-Garrote, Stefan Börjesson, Sara Hæggman, Vincent Perreten, Christopher J. Teale, Andrew S. Waller, Bruno Pichon, Martin D. Curran, Matthew J. Ellington, John J. Welch, Sharon J. Peacock, David J. Seilly, Fiona J. E. Morgan, Julian Parkhill, Nazreen F. Hadjirin, Jodi A. Lindsay, Matthew T. G. Holden, Giles F. Edwards, Geoffrey Foster, Gavin K. Paterson, Xavier Didelot, Mark A. Holmes, Ewan M. Harrison, Anders R. Larsen |
| المساهمون: | Larsen, Jesper [0000-0003-0582-0457], Ba, Xiaoliang [0000-0002-3882-3585], Padilla-González, Guillermo F [0000-0002-8300-6891], Černá Bolfíková, Barbora [0000-0001-8059-4889], Skov, Robert L [0000-0002-6079-5381], Rasmussen, Sophie L [0000-0002-2975-678X], Espinosa-Gongora, Carmen [0000-0002-9536-0548], Aarestrup, Frank M [0000-0002-7116-2723], Becker, Karsten [0000-0002-6391-1341], Layer, Franziska [0000-0002-4613-6478], Moroni, Paolo [0000-0002-0974-3084], Jørgensen, Hannah J [0000-0002-1788-9219], de Lencastre, Hermínia [0000-0001-6816-8932], Cercenado, Emilia [0000-0002-5279-3773], Börjesson, Stefan [0000-0003-2219-2659], Waller, Andrew S [0000-0002-7111-9549], Welch, John [0000-0001-7049-7129], Peacock, Sharon [0000-0002-1718-2782], Morgan, Fiona [0000-0003-0583-7996], Parkhill, Julian [0000-0002-7069-5958], Holden, Matthew TG [0000-0002-4958-2166], Foster, Geoffrey [0000-0002-5527-758X], Paterson, Gavin K [0000-0002-1880-0095], Didelot, Xavier [0000-0003-1885-500X], Holmes, Mark [0000-0002-5454-1625], Harrison, Ewan [0000-0003-2720-0507], Apollo - University of Cambridge Repository, Peacock, Sharon J [0000-0002-1718-2782], Holmes, Mark A [0000-0002-5454-1625], Harrison, Ewan M [0000-0003-2720-0507], University of St Andrews. School of Medicine, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. St Andrews Bioinformatics Unit, University of St Andrews. Infection and Global Health Division |
| المصدر: | Larsen, Jesper; Raisen, Claire L; Ba, Xiaoliang; Sadgrove, Nicholas J; Padilla-González, Guillermo F; Simmonds, Monique S J; Loncaric, Igor; Kerschner, Heidrun; Apfalter, Petra; Hartl, Rainer; Deplano, Ariane; Vandendriessche, Stien; Černá Bolfíková, Barbora; Hulva, Pavel; Arendrup, Maiken C; Hare, Rasmus K; Barnadas, Céline; Stegger, Marc; Sieber, Raphael N; Skov, Robert L; ... (2022). Emergence of methicillin resistance predates the clinical use of antibiotics. Nature, 602(7895), pp. 135-141. Springer Nature Limited 10.1038/s41586-021-04265-w <http://dx.doi.org/10.1038/s41586-021-04265-wTest> Larsen, J, Raisen, C L, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Ariane Deplano, A, Vandendriessche, S, Bolfíková, B Č, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L, Nykäsenoja, S, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, J. Teale, C, Waller, A, Pichon, B, Curran, M, Ellington, M, Welch, J, Peacock, S, Seilly, D, Morgan, F, Parkhill, J, Hadjirin, N, Lindsay, J, Holden, M T G, Edwards, G F, Foster, G, Paterson, G, Didelot, X, Holmes, M, Harrison, E & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, no. 7895, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-wTest Larsen, J, Raisen, C L, Ba, X, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Deplano, A, Vandendriessche, S, Černá Bolfíková, B, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L J, Nykäsenoja, S M, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H J, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, Teale, C J, Waller, A S, Pichon, B, Curran, M D, Ellington, M J, Welch, J J, Peacock, S J, Seilly, D J, Morgan, F J E, Parkhill, J, Hadjirin, N F, Lindsay, J A, Holden, M T G, Edwards, G F, Foster, G, Paterson, G K, Didelot, X, Holmes, M A, Harrison, E M & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135–141 . https://doi.org/10.1038/s41586-021-04265-wTest Paterson, G K 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-wTest |
| بيانات النشر: | Springer Nature Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Denmark, Geographic Mapping, Methicillin Resistance/genetics, Antimicrobial resistance, Bacterial evolution, Penicillins/biosynthesis, Phylogeny, beta-Lactams/metabolism, Multidisciplinary, 630 Agriculture, article, QR Microbiology, Anti-Bacterial Agents, Europe, Hedgehogs, Hedgehogs/metabolism, Methicillin-Resistant Staphylococcus aureus, 631/326/41/2529, 45/22, 45/23, 101/58, Anti-Bacterial Agents/history, Penicillins, beta-Lactams, Selection, Genetic/genetics, Evolution, Molecular, SDG 3 - Good Health and Well-being, 631/92/349/977, 631/158/1745, Animals, Humans, One Health, Selection, Genetic, SDG 2 - Zero Hunger, MCC, Infectious-disease epidemiology, QL, Arthrodermataceae/genetics, Arthrodermataceae, DAS, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, History, 20th Century, QR, 631/326/41/1470, 631/326/22/1434, 570 Life sciences, biology, Methicillin Resistance, Methicillin-Resistant Staphylococcus aureus/genetics, New Zealand |
| الوصف: | X.D. was funded by a grant from the National Institute for Health Research (NIHR) Health Protection Research Unit in Genomics and Enabling Data (no. NIHR200892). M.A.H. was supported by grants from the Medical Research Council (nos. G1001787/1, MR/N002660/1 and MR/P007201/1) and the Economic and Social Research Council (no. ES/S000186/1). E.M.H. was supported by a UK Research and Innovation (UKRI) Fellowship (no. MR/S00291X/1). The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics1. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus—a notorious human pathogen—appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two β-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development. Publisher PDF |
| وصف الملف: | application/pdf; application/zip; text/xml |
| تدمد: | 1476-4687 0028-0836 |
| DOI: | 10.48350/165217 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c43e8cd39a109234141bcbc266c126Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f8c43e8cd39a109234141bcbc266c126 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764687 00280836 |
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| DOI: | 10.48350/165217 |