Intussusceptive pillar formation in developing porcine glomeruli
| العنوان: | Intussusceptive pillar formation in developing porcine glomeruli |
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| المؤلفون: | Tim Vandecasteele, Ward De Spiegelaere, Wim Van Den Broeck, Ingrid Walter, Pieter Cornillie, Anastasia Logothetidou, Waltraud Tschulenk |
| المصدر: | JOURNAL OF VASCULAR RESEARCH |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Endothelium, Physiology, Angiogenesis, Organogenesis, Kidney Glomerulus, Sus scrofa, Neovascularization, Physiologic, Gestational Age, 030226 pharmacology & pharmacy, ANGIOGENESIS, law.invention, MECHANISMS, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, KIDNEY, Microscopy, Electron, Transmission, INFLAMMATION, law, medicine, Animals, Intussusceptive angiogenesis, RECONSTRUCTION, Chemistry, MICROVASCULAR GROWTH, Pillar, Endothelial Cells, Biology and Life Sciences, Metanephros, VASCULAR MORPHOGENESIS, Cell biology, Glomerular capillary, Capillaries, Extracellular Matrix, MODEL, 030104 developmental biology, medicine.anatomical_structure, CELLS, Glomerulus, sense organs, Electron microscope, Cardiology and Cardiovascular Medicine, MATRIX, Metanephric kidney, Intraluminal pillar |
| الوصف: | Background/Aims: Intussusceptive angiogenesis (IA) is a dynamic process which contributes to vascular expansion and remodeling. Intraluminal pillars have long been the distinctive structural indicator of IA. However, the mechanism of their formation has not been fully elucidated. Methods: Using light and electron microscopy, we studied intussusceptive vascular growth in the developing porcine metanephric kidney. Results: We observed intraluminal pillars formed by endothelial cells in the vasculature of developing glomeruli. Their diameter was < 2.5 µm, consistent with the diameter of nascent pillars. TEM revealed that the majority of these pillars consisted only of endothelium. However, a central core of extracellular matrix (ECM) covered by endothelium, reminiscent of a more mature intussusceptive pillar, was also found in the lumen of a glomerular capillary. Perivascular cells or pericytes were not involved in the pillar structure during these stages of formation. Conclusion: This study shows ECM presence in a mature intussusceptive pillar without any perivascular cell involvement in the structure. This leads to the hypothesis that ECM deposition precedes the participation of these cells in the formation of intraluminal pillars during IA in porcine metanephric glomerular capillaries. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1018-1172 1423-0135 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89a9e92e924126883493eaef15c712eTest https://hdl.handle.net/1854/LU-8573905Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f89a9e92e924126883493eaef15c712e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10181172 14230135 |
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