Preproinsulin-Specific CD8+T Cells Secrete IFNγ in Human Type 1 Diabetes
| العنوان: | Preproinsulin-Specific CD8+T Cells Secrete IFNγ in Human Type 1 Diabetes |
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| المؤلفون: | Michael Schlosser, Ivana Durinovic-Belló, Silke Rosinger, Silvia Rathmann, Thomas Eiermann, Bernhard O. Boehm, Tarvo Rajasalu |
| المصدر: | Annals of the New York Academy of Sciences. 1037:22-25 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | endocrine system, Preproinsulin, Time Factors, endocrine system diseases, T-Lymphocytes, Antigen-Presenting Cells, Enzyme-Linked Immunosorbent Assay, Pilot Projects, CD8-Positive T-Lymphocytes, Biology, Autoantigens, General Biochemistry, Genetics and Molecular Biology, Interferon-gamma, Interleukin 21, HLA-DR3 Antigen, History and Philosophy of Science, immune system diseases, HLA-DQ Antigens, HLA-A2 Antigen, HLA-DR4 Antigen, Humans, Insulin, Cytotoxic T cell, Receptor-Like Protein Tyrosine Phosphatases, Class 8, Secretion, IL-2 receptor, Protein Precursors, Autoantibodies, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Glutamate Decarboxylase, General Neuroscience, Membrane Proteins, nutritional and metabolic diseases, Peptide Fragments, Diabetes Mellitus, Type 1, Immunology, Leukocytes, Mononuclear, Cytokine secretion, Interleukin-4, Protein Tyrosine Phosphatases, CD8, Proinsulin, CD81 |
| الوصف: | In animal models autoreactive CD8(+) T cells are crucial in the development of type 1 diabetes (T1D); however, their role in human T1D is still not known. To address the role of CD81 T cells we performed a pilot study by investigating CD8(+) T cell-mediated cytokine secretion after in vitro stimulation with 94 preproinsulin (PPI) peptides. We were able to show that CD8(+) T cells contribute to a strong IFNgamma reactivity against PPI in human T1D. Further investigations defining epitope specificity, cytokine secretion, and cytotoxic capacity are important to clarify their role in T1D development. |
| تدمد: | 1749-6632 0077-8923 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f899138abc9745321a66e67c79bb5635Test https://doi.org/10.1196/annals.1337.004Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f899138abc9745321a66e67c79bb5635 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17496632 00778923 |
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