Aminodextran Coated CoFe2O4 Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia
| العنوان: | Aminodextran Coated CoFe2O4 Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia |
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| المؤلفون: | Nasir M. Ahmad, Noureddine Lebaz, Abdelhamid Elaissari, Muhammad Asif Hamayun, Sumera Khizar, Michele K L Tenório, Nauman Naseer, Sadia Manzoor, Naveed Ahmed |
| المساهمون: | National University of Sciences and Technology [Islamabad] (NUST), Quaid-i-Azam University (QAU), COMSATS University Islamabad (CUI), King Edward Medical University (KEMU), Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique (LAGEPP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Universidade Estadual de Ponta Grossa - State University of Ponta Grossa (UEPG) |
| المصدر: | Nanomaterials Volume 10 Issue 11 Nanomaterials, MDPI, 2020, 10 (11), pp.2182. ⟨10.3390/nano10112182⟩ Nanomaterials, Vol 10, Iss 2182, p 2182 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Hyperthermia, Materials science, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, General Chemical Engineering, theranostic, Nanoparticle, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Article, lcsh:Chemistry, Magnetization, Adsorption, medicine, Zeta potential, General Materials Science, magnetic particles, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, medicine.disease, equipment and supplies, 3. Good health, 0104 chemical sciences, in vitro diagnosis, lcsh:QD1-999, Chemical engineering, adsorption, Magnetic nanoparticles, Surface modification, functionalization, Absorption (chemistry), 0210 nano-technology, human activities, MRI |
| الوصف: | Aminodextran (AMD) coated magnetic cobalt ferrite nanoparticles are synthesized via electrostatic adsorption of aminodextran onto magnetic nanoparticles and their potential theranostic application is evaluated. The uncoated and aminodextran-coated nanoparticles are characterized to determine their hydrodynamic size, morphology, chemical composition, zeta potential and magnetization. The aminodextran containing cobalt ferrite nanoparticles of nanometer size are positively charged in the pH range from 3 to 9 and exhibit saturation magnetization of 50 emu/g. The magnetic resonance imaging (MRI) indicates capability for diagnostics and a reduction in intensity with an increase in nanoparticle amount. The hyperthermia capability of the prepared particles shows their potential to generate suitable local heat for therapeutic purposes. There is a rise of 7 ° C and 9 ° C at 327 kHz and 981 kHz respectively and specific absorption rates (SAR) of aminodextran-coated nanoparticles are calculated to be 259 W/g and 518 W/g at the given frequencies larger than uncoated nanoparticles (0.02 W/g). The development of novel aminodextran coated magnetic cobalt ferrite nanoparticles has significant potential to enable and improve personalized therapy regimens, targeted cancer therapies and ultimately to overcome the prevalence of nonessential and overdosing of healthy tissues and organs. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2079-4991 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f838fc76eb4a24bb35ec4e7ae75c2b76Test http://europepmc.org/articles/PMC7692372Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f838fc76eb4a24bb35ec4e7ae75c2b76 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20794991 |
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