Early sign of atherosclerosis in slow coronary flow and relationship with angiotensin-converting enzyme I/D polymorphism
| العنوان: | Early sign of atherosclerosis in slow coronary flow and relationship with angiotensin-converting enzyme I/D polymorphism |
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| المؤلفون: | Ceren Acar, Harun Evrengul, Deniz Seleci, Asuman Kaftan, Seyhan Tanriverdi, Halil Tanriverdi, Omur Kuru, Hatice Mergen |
| المصدر: | Heart and Vessels. 22:1-8 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Carotid Artery Diseases, Male, angiocardiography, AT1R A/C1166 polymorphism, Adult, Aged, Alleles, Carotid Artery Diseases/*genetics/*physiopathology, Coronary Angiography, Coronary Vessels/*physiopathology, Female, Humans, Middle Aged, Peptidyl-Dipeptidase A/*genetics, Polymorphism, Genetic/*physiology, Regional Blood Flow, Renin-Angiotensin System, Tunica Intima/pathology, Tunica Media/pathology, Intima-media thickness, correlation analysis, genotype, Renin-angiotensin gene system, image display, Coronary artery disease, cardiovascular disease, Carotid atherosclerosis, coronary artery blood flow, renin angiotensin aldosterone system, Myocardial infarction, Common carotid artery, statistical significance, clinical article, biology, adult, pathogenesis, artery intima, allele, article, vascular disease, Coronary Vessels, transducer, ACEI/D polymorphism, aged, female, medicine.anatomical_structure, priority journal, risk factor, Cardiology, Tunica Media, Cardiology and Cardiovascular Medicine, coronary artery disease, gene insertion, TIMI, medicine.medical_specialty, regulatory mechanism, angiotensin 1 receptor, dipeptidyl carboxypeptidase, common carotid artery, Peptidyl-Dipeptidase A, artery media, Internal medicine, medicine.artery, medicine, inheritance, controlled study, human, cardiovascular diseases, artery wall, Polymorphism, Genetic, Slow coronary flow, carotid artery, gene deletion, business.industry, disease association, echography, Angiotensin-converting enzyme, medicine.disease, Angiotensin II, thickness, Coronary arteries, enzyme polymorphism, biology.protein, Gene polymorphism, atherosclerosis, Tunica Intima, business |
| الوصف: | Increase in carotid artery intima-media thickness (IMT) is an early sign of atherosclerosis. Slow coronary flow (SCF) is characterized by delay of opacification of coronary arteries in coronary angiography in the absence of any evident obstructive lesion, but its etiopathogenesis remains unclear. Genes that regulate the renin angiotensin system also play a role in developing cardiovascular system disorders. The presence of deletion (D) allele in angiotensin converting enzyme (ACE) gene polymorphism is associated with coronary artery disease. The aim of this study was to investigate the carotid artery IMT measurement, as an early sign of atherosclerosis, in patients with SCF and without SCF and also to assess the effect of the renin-angiotensin gene system on carotid IMT. Forty-four patients with angiographically proven SCF and 44 cases with normal coronary flow (NCF) pattern with similar risk profile were enrolled in the study. Coronary flow patterns of the cases were determined by thrombolysis in myocardial infarction (TIMI) frame count method. Intima-media thickness was measured by recording ultrasonographic images of both the left and right common carotid artery with a 12-MHz linear array transducer. ACE I/D polymorphism and Angiotensin II tip 1 receptor (AT1R) A/C gene polymorphism were determined by polymerase chain reaction (PCR) amplification. Demographic characteristics and coronary artery disease risk factors of SCF and NCF groups were similar. Mean TIMI frame count and carotid IMT (mm) were significantly higher in the SCF group than controls (45.9 ± 12 vs 23.3 ± 3.7, P = 0.0001; 0.75 ± 0.08 vs 0.69 ± 0.06, P = 0.0001, respectively). Mean TIMI frame count was positively correlated with IMT of carotid artery in correlation analysis (r = 0.45, P = 0.0001). When analyzed in regard to ACE genotype in all subjects, IMT values were statistically different (0.78 ± 0.06 for DD genotype, 0.72 ± 0.05 for ID genotype, and 0.64 ± 0.06 for II genotype, P = 0.0001). This difference remained significant in subgroup analyses for each genotype. No association could be observed between the AT1R A/C1166 polymorphism and IMT of carotid artery measurement (P > 0.05). Lack of association was still observed with analysis carried out when genotype effect was assumed to be inherited as additive (CC versus AA versus AC) or dominant (AA versus AC+CC). Increased IMT in patients with SCF shows that subclinical atherosclerosis may play role in this phenomenon. This increase was most marked in the presence of D allele of ACE genotype, which is associated with vascular hypertrophy. © Springer-Verlag Tokyo 2007. |
| تدمد: | 1615-2573 0910-8327 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d718dcd247dbc8ffed8d0c8678ed4eTest https://doi.org/10.1007/s00380-006-0925-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f7d718dcd247dbc8ffed8d0c8678ed4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16152573 09108327 |
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