‘A Single Night’ Beneficial Effects of Adaptive Servo-Ventilation on Cardiac Overload, Sympathetic Nervous Activity, and Myocardial Damage in Patients With Chronic Heart Failure and Sleep-Disordered Breathing
| العنوان: | ‘A Single Night’ Beneficial Effects of Adaptive Servo-Ventilation on Cardiac Overload, Sympathetic Nervous Activity, and Myocardial Damage in Patients With Chronic Heart Failure and Sleep-Disordered Breathing |
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| المؤلفون: | Makiko Miyata, Hiroyuki Kunii, Takayoshi Yamaki, Kazuhiko Nakazato, Akiomi Yoshihisa, Koichi Sugimoto, Hitoshi Suzuki, Satoshi Suzuki, Yasuchika Takeishi, Shu-ichi Saitoh |
| المصدر: | Circulation Journal. 76:2153-2158 |
| بيانات النشر: | Japanese Circulation Society, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Sympathetic Nervous System, Central sleep apnea, Polysomnography, Troponin T, Atrial natriuretic peptide, Internal medicine, Heart rate, Humans, Medicine, cardiovascular diseases, Aged, Heart Failure, Sleep Apnea, Obstructive, Cross-Over Studies, Ejection fraction, medicine.diagnostic_test, business.industry, Myocardium, Sleep apnea, General Medicine, Middle Aged, medicine.disease, respiratory tract diseases, Oxygen, Apnea–hypopnea index, Anesthesia, Heart failure, Chronic Disease, cardiovascular system, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Atrial Natriuretic Factor |
| الوصف: | Background: Sleep-disordered breathing (SDB), including Cheyne-Stokes respiration with central sleep apnea (CSR-CSA), causes a deterioration in the prognosis of patients with chronic heart failure (CHF). Adaptive servo-ventilation (ASV) and oxygen therapy (O2) are useful for improving the CSR-CSA of CHF. The purpose of the present study was to examine the short-term effects of ASV and O2 on suppressing SDB (CSR-CSA dominant) in CHF, and the accompanying neurohumoral abnormalities (cardiac overload, sympathetic nervous activation, and myocardial damage). Methods and Results: Forty-two patients with CHF and SDB (mean LVEF 34.6%, apnea hypopnea index (AHI) 39.0/h, central apnea index (CAI) 17.6/h, obstructive apnea index (OAI) 2.6/h) were enrolled. We performed polysomnography (baseline, O2, and ASV) for 3 consecutive days, and we measured levels of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), noradrenalin, urinary catecholamines, and high-sensitivity troponin T. Both O2 and ASV reduced the AHI, CAI, arousal index, mean heart rate during sleep, and the levels of noradrenalin, urinary catecholamines, and high-sensitivity troponin T. However, only ASV, not O2, decreased the levels of ANP and BNP. Conclusions: ASV reduces cardiac overload, attenuates sympathetic nervous activity and ongoing myocardial damage effectively in CHF patients with SDB, and for patients who cannot use ASV, O2 is an alternative therapy. (Circ J 2012; 76: 2153–2158) |
| تدمد: | 1347-4820 1346-9843 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a0a4be46f24501e33f8bed2ea4be96Test https://doi.org/10.1253/circj.cj-12-0453Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f7a0a4be46f24501e33f8bed2ea4be96 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474820 13469843 |
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