Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations
| العنوان: | Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations |
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| المؤلفون: | Nicholas J. Wareham, Carol A. Wang, Daniel I. Chasman, Yasmin Mossavar-Rahmani, Jordi Merino, Ruifang Li-Gao, Jessica C. Kiefte-de Jong, Rozenn N. Lemaitre, Paul M. Ridker, Kent D. Taylor, Gina M. Peloso, Achilleas N. Pitsillides, Craig E. Pennell, Wendy H. Oddy, Linda Snetselaar, Kim V.E. Braun, Nathan L. Tintle, Alice H. Lichtenstein, Nita G. Forouhi, James B. Meigs, Alexis C. Wood, M. Arfan Ikram, Fumiaki Imamura, Melanie Guirette, Jason Westra, Jorma Viikari, Frits R. Rosendall, Kristin L. Young, Dennis O. Mook-Kanamori, Renée de Mutsert, Jian'an Luan, Mika Helminen, Dariush Mozaffarian, Jerome I. Rotter, Niina Pitkänen, Danielle E. Haslam, Olli T. Raitakari, Steven Rich, JoAnn E. Manson, Trudy Voortman, Nicola M. McKeown, Mariaelisa Graff, Mohsen Ghanbari, Josée Dupuis, Mark A. Herman, Kari E. North, Terho Lehtimäki, Caren E. Smith, Bruce M. Psaty, Hassan S. Dashti, Samia Mora, Traci M. Bartz, André G. Uitterlinden, Kara A Livingston, Mika Kähönen, Lisa W. Martin |
| المساهمون: | Imamura, Fumiaki [0000-0002-6841-8396], Luan, Jian'an [0000-0003-3137-6337], Forouhi, Nita [0000-0002-5041-248X], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Epidemiology, Radiology & Nuclear Medicine, Internal Medicine, Tampere University, Department of Clinical Physiology and Nuclear Medicine, Clinical Medicine, Tays Research Services, Health Sciences, Department of Clinical Chemistry |
| المصدر: | Circulation. Genomic and Precision Medicine Circulation: Genomic and Precision Medicine, 14(4):E003288. Lippincott Williams & Wilkins Circulation. Genomic and precision medicine, vol 14, iss 4 Circulation: Genomic and Precision Medicine, 14(4), 506-516. LIPPINCOTT WILLIAMS & WILKINS |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, carbohydrates, Cardiovascular, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, genetics, 030212 general & internal medicine, Sugar-Sweetened Beverages, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, General Medicine, Single Nucleotide, Middle Aged, Cholesterol, nutrition, Biochemistry, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, epidemiology, Adult, HDL, Locus (genetics), Polymorphism, Single Nucleotide, 03 medical and health sciences, Meta-Analysis as Topic, Genetics, Humans, triglyceride, Polymorphism, Sugar, Carbohydrate-responsive element-binding protein, Transcription factor, Triglycerides, Triglyceride, Human Genome, Cholesterol, HDL, dyslipidemia, Original Articles, Carbohydrate, 3141 Health care science, stomatognathic diseases, 030104 developmental biology, chemistry, sugars, 3111 Biomedicine |
| الوصف: | Supplemental Digital Content is available in the text. Background: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia. Methods: Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake. Results: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16–3.07] mg/dL per allele; P |
| وصف الملف: | application/pdf; fulltext |
| تدمد: | 2574-8300 7155-6729 1942-325X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79f5b7970d97657e4899131197c4caaTest https://pubmed.ncbi.nlm.nih.gov/34270325Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f79f5b7970d97657e4899131197c4caa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25748300 71556729 1942325X |
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