Cardioprotective effects of GLP-1(28-36a): A degraded metabolite or GLP-1's better half?
| العنوان: | Cardioprotective effects of GLP-1(28-36a): A degraded metabolite or GLP-1's better half? |
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| المؤلفون: | Katsumi Iizuka, Daisuke Yabe, Sodai Kubota, Yangyang Liu |
| المصدر: | Journal of Diabetes Investigation Journal of Diabetes Investigation, Vol 11, Iss 6, Pp 1422-1425 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cardiotonic Agents, Endocrinology, Diabetes and Metabolism, Metabolite, 030209 endocrinology & metabolism, Pharmacology, Diseases of the endocrine glands. Clinical endocrinology, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adenosine Triphosphate, Glucagon-Like Peptide 1, Commentaries, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Cyclic adenosine monophosphate, Protein kinase A, education, education.field_of_study, business.industry, Pinocytosis, General Medicine, Soluble adenylyl cyclase, RC648-665, Prognosis, Adenosine, Cytoprotection, Peptide Fragments, 030104 developmental biology, chemistry, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Commentary, business, Adenosine triphosphate, medicine.drug, Signal Transduction |
| الوصف: | Molecular mechanism underlying glucagon-like peptide-1 exertion of cardioprotective effects in glucagon-like peptide-1 receptor-dependent and -independent manners. Glucagon-like peptide-1 (28-36a) enters coronary artery endothelial cells through macropinocytosis and binds to mitochondrial trifunctional protein-α, shifting substrate utilization to increase adenosine triphosphate production and modulating a adenosine triphosphate-sensor soluble adenylyl cyclase, thereby producing cyclic adenosine monophosphate and activating protein kinase A to exert cytoprotection from oxidative injury. |
| تدمد: | 2040-1124 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f723c66d952b65d7b8b3a65732d680acTest https://pubmed.ncbi.nlm.nih.gov/32428993Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f723c66d952b65d7b8b3a65732d680ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401124 |
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