The Plasminogen Activator System in Young and Lean Women with Polycystic Ovary Syndrome
| العنوان: | The Plasminogen Activator System in Young and Lean Women with Polycystic Ovary Syndrome |
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| المؤلفون: | Pinar Tarkun, Ilhan Tarkun, Berrin Ç. Arslan, Erdem Türemen, Zeynep Cantürk |
| المصدر: | Endocrine Journal. 51:467-472 |
| بيانات النشر: | Japan Endocrine Society, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Blood Glucose, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Anovulation, chemistry.chemical_compound, Endocrinology, Insulin resistance, Sex hormone-binding globulin, Risk Factors, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Insulin, Gonadal Steroid Hormones, biology, medicine.diagnostic_test, business.industry, Body Weight, nutritional and metabolic diseases, medicine.disease, Lipids, Polycystic ovary, chemistry, Plasminogen activator inhibitor-1, biology.protein, Female, Insulin Resistance, business, Lipid profile, Plasminogen activator, Polycystic Ovary Syndrome |
| الوصف: | The purpose of the study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) levels and PAI-1 activity in young and lean women with PCOS and to compare with controls matched for age and weight. Thirty two women with PCOS and 25 weight and age-matched healthy controls participated in this study. Patients were evaluated clinically and by pelvic ultrasound and fasting blood samples were taken for hematological and biochemical tests. Fasting insulin, glucose, lipid profile, FSH, LH, PRL, testosterone, SHBG, 17-hydroxyprogesterone, androstenedione, PAI-1 antigen; PAI-1 activity, insulin sensitivity indices (HOMA and QUICKI) were measured. PAI-1 Ag and activity were significantly higher in PCOS women than healthy control group. PAI-1 levels were directly correlated with BMI, insulin levels and insulin sensitivity indices. PAI-1 activity was also correlated with insulin levels and insulin resistance. As a conclusion PAI-1 Ag levels and activity were increased in lean PCOS women and these were directly correlated with insulin resistance. The finding may contribute to evidence of increase risk of cardiovascular disease and anovulatory infertility in PCOS women. |
| تدمد: | 1348-4540 0918-8959 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70ade8a7447d70c23756d02dfe024e0Test https://doi.org/10.1507/endocrj.51.467Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f70ade8a7447d70c23756d02dfe024e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13484540 09188959 |
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