Incretin secretion in humans is under the influence of cannabinoid receptors
| العنوان: | Incretin secretion in humans is under the influence of cannabinoid receptors |
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| المؤلفون: | Josephine M. Egan, Sara Santa-Cruz Calvo, Isabel González-Mariscal, Olga D. Carlson, Chee W. Chia, David D. Liu |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 313:E359-E366 |
| بيانات النشر: | American Physiological Society, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, Cannabinoid receptor, Physiology, Endocrinology, Diabetes and Metabolism, Incretin, Gastric Inhibitory Polypeptide, Biology, Incretins, Young Adult, 03 medical and health sciences, Double-Blind Method, Glucagon-Like Peptide 1, Physiology (medical), Internal medicine, medicine, Humans, Secretion, Dronabinol, Longitudinal Studies, Obesity, Prospective Studies, Receptors, Cannabinoid, Human obesity, Cannabinoid Receptor Agonists, Cross-Over Studies, digestive, oral, and skin physiology, Glucose Tolerance Test, Middle Aged, Endocannabinoid system, 030104 developmental biology, Endocrinology, Case-Control Studies, Female, hormones, hormone substitutes, and hormone antagonists, Research Article |
| الوصف: | The mechanisms regulating incretin secretion are not fully known. Human obesity is associated with altered incretin secretion and elevated endocannabinoid levels. Since cannabinoid receptors (CBRs) are expressed on incretin-secreting cells in rodents, we hypothesized that endocannabinoids are involved in the regulation of incretin secretion. We compared plasma glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) responses during oral glucose tolerance test (OGTT) in 20 lean and 20 obese participants from the Baltimore Longitudinal Study of Aging (BLSA). Next, we recruited 20 healthy men to evaluate GIP and GLP-1 responses during OGTT after administering placebo or nabilone (CBR agonist) in a randomized, double-blind, crossover fashion. Compared with the BLSA lean group, the BLSA obese group had significantly higher fasting and post-OGTT GIP levels, but similar fasting GLP-1 and significantly lower post-OGTT GLP-1 levels. In the nabilone vs. placebo study, when compared with placebo, nabilone resulted in significantly elevated post-dose fasting GIP levels and post-OGTT GIP levels, but no change in post-dose fasting GLP-1 levels together with significantly lower post-OGTT GLP-1 levels. Glucose levels were not different with both interventions. We conclude that elevated GIP levels in obesity are likely a consequence of increased endocannabinoid levels. CBRs exert tonic control over GIP secretion, which may have a homeostatic effect in suppressing GLP-1 secretion. This raises the possibility that gut hormones are influenced by endocannabinoids. |
| تدمد: | 1522-1555 0193-1849 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f708e84deeef899fbf28bfc211c943ddTest https://doi.org/10.1152/ajpendo.00080.2017Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f708e84deeef899fbf28bfc211c943dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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