Early-Onset Frontotemporal Dementia-Related Semantic Variant of Primary Progressive Aphasia
| العنوان: | Early-Onset Frontotemporal Dementia-Related Semantic Variant of Primary Progressive Aphasia |
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| المؤلفون: | Athanasios Papadopoulos, Spyridon Konitsiotis, Spyridon Tsiouris, Andreas Fotopoulos, Charalampos Bougias |
| المصدر: | Clinical Nuclear Medicine. 47:260-264 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Hippocampus, Perfusion scanning, computer.software_genre, Amygdala, Primary progressive aphasia, Atrophy, Voxel, mental disorders, medicine, Humans, Radiology, Nuclear Medicine and imaging, Tomography, Emission-Computed, Single-Photon, business.industry, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Temporal Lobe, Semantics, Perfusion, Aphasia, Primary Progressive, medicine.anatomical_structure, Frontotemporal Dementia, Radiology, Alzheimer's disease, business, computer, Frontotemporal dementia |
| الوصف: | Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by cortical and subcortical atrophies, with early involvement of the hippocampus and amygdala. A 58-year-old man with clinical presentation of primary progressive aphasia-particularly its svPPA (semantic variant)-and bilateral asymmetric (left-predominant) anterior temporal lobe atrophy on MRI was referred for brain perfusion SPECT. This revealed bilateral hypoperfusion of the anterior temporal lobe (sustained by software-fused SPECT/MRI), pointing toward FTD rather than Alzheimer disease. Furthermore, voxel-based MRI volumetric analysis confirmed bilateral atrophy affecting the hippocampus and amygdala. Combining SPECT with MRI was supportive of the early-onset FTD-related svPPA diagnosis. |
| تدمد: | 1536-0229 0363-9762 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ada6811f784895f9747559cac85d5bTest https://doi.org/10.1097/rlu.0000000000003934Test |
| رقم الانضمام: | edsair.doi.dedup.....f6ada6811f784895f9747559cac85d5b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15360229 03639762 |
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