Vagus Nerve Stimulation Attenuates Hepatic Ischemia/Reperfusion Injury via the Nrf2/HO-1 Pathway
| العنوان: | Vagus Nerve Stimulation Attenuates Hepatic Ischemia/Reperfusion Injury via the Nrf2/HO-1 Pathway |
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| المؤلفون: | Meng Wang, Yanqiu Lai, Jielin Deng, Yifeng Zhang, Xiaoya Zhou, Hong Jiang, Qianqian Zhang, Xiaomeng Yang, Menglong Wang, Zhenya Wang |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) |
| بيانات النشر: | Hindawi, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, Article Subject, Vagus Nerve Stimulation, NF-E2-Related Factor 2, medicine.medical_treatment, Ischemia, Inflammation, Apoptosis, medicine.disease_cause, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Internal medicine, Lactate dehydrogenase, medicine, Animals, lcsh:QH573-671, business.industry, lcsh:Cytology, Liver Diseases, Sham surgery, Cell Biology, General Medicine, medicine.disease, Vagus nerve, Rats, Disease Models, Animal, Oxidative Stress, Endocrinology, chemistry, Reperfusion Injury, Heme Oxygenase (Decyclizing), medicine.symptom, business, Reperfusion injury, Vagus nerve stimulation, Oxidative stress, Research Article |
| الوصف: | It has been demonstrated that vagus nerve stimulation (VNS) plays a protective role in ischemia/reperfusion (I/R) injury of various organs. The present study investigates the protective effect of VNS on hepatic I/R injury and the potential mechanisms. Male Sprague-Dawley rats were randomly allocated into three groups: the sham operation group (Sham; n=6, sham surgery with sham VNS); the I/R group (n=6, hepatic I/R surgery with sham VNS); and the VNS group (n=6, hepatic I/R surgery plus VNS). The I/R model was established by 1 hour of 70% hepatic ischemia. Tissue samples and blood samples were collected after 6 hours of reperfusion. The left cervical vagus nerve was separated and stimulated throughout the whole I/R process. The stimulus intensity was standardized to the voltage level that slowed the sinus rate by 10%. VNS significantly reduced the necrotic area and cell death in I/R tissues. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) were also decreased by VNS. In addition, VNS suppressed inflammation, oxidative stress, and apoptosis in I/R tissues. VNS significantly increased the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) in the liver. These data indicated that VNS may attenuate hepatic I/R injury by inhibiting inflammation, oxidative stress, and apoptosis possibly via the Nrf2/HO-1 pathway. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1942-0994 1942-0900 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69752c760ec806e4b2f790926b5b712Test http://europepmc.org/articles/PMC6530204Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f69752c760ec806e4b2f790926b5b712 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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