Accuracy of a nomogram for prediction of lymph-node metastasis detected with conventional histopathology and ultrastaging in endometrial cancer
| العنوان: | Accuracy of a nomogram for prediction of lymph-node metastasis detected with conventional histopathology and ultrastaging in endometrial cancer |
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| المؤلفون: | Denis Heitz, Henri Marret, Denis Querleu, Marcos Ballester, Dominique Luton, Emile Daraï, Martin Koskas, François Golfier, Gil Dubernard, Eric Leblanc, Fabrice Lecuru, Roman Rouzier, Elisabeth Chereau, Patrice Mathevet |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Oncology, micrometastasis, Cancer Research, medicine.medical_specialty, macrometastasis, Metastasis, Immunoenzyme Techniques, Internal medicine, medicine, Humans, Stage (cooking), Macrometastasis, Aged, Neoplasm Staging, Pelvic Neoplasms, Receiver operating characteristic, Sentinel Lymph Node Biopsy, business.industry, Endometrial cancer, Micrometastasis, Nomogram, Prognosis, medicine.disease, Carcinoma, Papillary, Cystadenocarcinoma, Serous, Endometrial Neoplasms, Nomograms, ROC Curve, sentinel node, Neoplasm Micrometastasis, Area Under Curve, Lymphatic Metastasis, endometrial cancer, immunohistochemistry, Clinical Study, lymph-node metastasis, Lymph Node Excision, Female, Histopathology, Radiology, business, Adenocarcinoma, Clear Cell, Follow-Up Studies |
| الوصف: | Background: We developed a nomogram based on five clinical and pathological characteristics to predict lymph-node (LN) metastasis with a high concordance probability in endometrial cancer. Sentinel LN (SLN) biopsy has been suggested as a compromise between systematic lymphadenectomy and no dissection in patients with low-risk endometrial cancer. Methods: Patients with stage I–II endometrial cancer had pelvic SLN and systematic pelvic-node dissection. All LNs were histopathologically examined, and the SLNs were examined by immunohistochemistry. We compared the accuracy of the nomogram at predicting LN detected with conventional histopathology (macrometastasis) and ultrastaging procedure using SLN (micrometastasis). Results: Thirty-eight of the 187 patients (20%) had pelvic LN metastases, 20 had macrometastases and 18 had micrometastases. For the prediction of macrometastases, the nomogram showed good discrimination, with an area under the receiver operating characteristic curve (AUC) of 0.76, and was well calibrated (average error =2.1%). For the prediction of micro- and macrometastases, the nomogram showed poorer discrimination, with an AUC of 0.67, and was less well calibrated (average error =10.9%). Conclusion: Our nomogram is accurate at predicting LN macrometastases but less accurate at predicting micrometastases. Our results suggest that micrometastases are an ‘intermediate state' between disease-free LN and macrometastasis. |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59a052493b8d3192cc5aed545e11dd4Test https://doi.org/10.1038/bjc.2013.95Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f59a052493b8d3192cc5aed545e11dd4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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