COVID-19 patients in a tertiary US hospital: Assessment of clinical course and predictors of the disease severity
| العنوان: | COVID-19 patients in a tertiary US hospital: Assessment of clinical course and predictors of the disease severity |
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| المؤلفون: | Denise L. Dalmacion, Chang Wang, Chandler Patton, Margaret Eng, Sharon Weiner, Ikwinder Preet Kaur, Violet Kramer, Sai Koyoda, Mohsin Sheraz Mughal, Kenneth Granet, Ali R. Jaffery |
| المصدر: | Respiratory Medicine |
| بيانات النشر: | Elsevier Ltd., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, medicine.medical_treatment, Pneumonia, Viral, Ventilators, Comorbidity, Respiratory failure, Risk Assessment, Severity of Illness Index, Article, Coronary artery disease, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Risk Factors, Internal medicine, Severity of illness, medicine, Humans, 030212 general & internal medicine, Mortality, Pandemics, Aged, Retrospective Studies, Mechanical ventilation, business.industry, SARS-CoV-2, Mortality rate, Age Factors, COVID-19, Retrospective cohort study, Odds ratio, Middle Aged, medicine.disease, Prognosis, Respiration, Artificial, United States, Hospitalization, Coronavirus, 030228 respiratory system, Female, business, Coronavirus Infections, Intubation, Ventilator Weaning |
| الوصف: | Introduction Patients with severe COVID-19 can develop ventilator-dependent acute hypoxic respiratory failure (VDAHRF), which is associated with a higher mortality rate. We evaluated the clinical course of hospitalized COVID-19 patients and compared them with the patients who received invasive mechanical ventilation. Characteristics of intubated patients who were successfully weaned from the ventilator were compared with the patients who failed to be extubated or died in the hospital. Objective To investigate the clinical course of hospitalized COVID-19 patients, and assess the possible predictors of the disease severity leading to VDAHRF. Methods This is a single-center, retrospective study. The first 129 patients (18 years or older) with COVID-19 admitted to Monmouth Medical Center from March 1st to April 25th, 2020 were included. Results Out of 129 patients, 23.25% (n = 30) required invasive mechanical ventilation, and of those, six patients were successfully weaned from the ventilator. Multivariable logistic regression analysis showed increased odds of intubation associated with hypoxemia (odds ratio 17.23, 95% CI 5.206–57.088; p Highlights • Out of 129 patients, 23.25% (n = 30) required invasive mechanical ventilation, six of whom were successfully extubated. Patients who required invasive mechanical ventilation were more likely to be older, male, and have coronary artery disease, diabetes, and obesity. • Multivariable logistic regression analysis showed increased odds of intubation associated with hypoxemia (odds ratio 17.23, 95% CI 5.206–57.088; p |
| اللغة: | English |
| تدمد: | 1532-3064 0954-6111 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d9b1f5b2ac1df6b10b59f650fd90c4Test http://europepmc.org/articles/PMC7455149Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f4d9b1f5b2ac1df6b10b59f650fd90c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15323064 09546111 |
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