GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis
| العنوان: | GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis |
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| المؤلفون: | Yan Chen, Ying-na Xu, Chen-yu Ye, Wen-bo Feng, Qing-tong Zhou, De-hua Yang, Ming-wei Wang |
| المصدر: | Acta Pharmacol Sin |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmacology, Diabetes Mellitus, Type 2, Glucagon-Like Peptide 1, Non-alcoholic Fatty Liver Disease, Humans, Hypoglycemic Agents, Pharmacology (medical), Obesity, Review Article, General Medicine, Glucagon-Like Peptide-1 Receptor |
| الوصف: | Nonalcoholic steatohepatitis (NASH), as a severe form of nonalcoholic fatty liver disease (NAFLD), is characterized by liver steatosis, inflammation, hepatocellular injury and different degrees of fibrosis. The pathogenesis of NASH is complex and multifactorial, obesity and type 2 diabetes mellitus (T2DM) have been implicated as major risk factors. Glucagon-like peptide-1 receptor (GLP-1R) is one of the most successful drug targets of T2DM and obesity, and its peptidic ligands have been proposed as potential therapeutic agents for NASH. In this article we provide an overview of the pathophysiology and management of NASH, with a special focus on the pharmacological effects and possible mechanisms of GLP-1 mimetics in treating NAFLD/NASH, including dual and triple agonists at GLP-1R, glucose-dependent insulinotropic polypeptide receptor or glucagon receptor. |
| تدمد: | 1745-7254 1671-4083 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f497742ba5c2179623cac352d557d8d1Test https://doi.org/10.1038/s41401-021-00836-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f497742ba5c2179623cac352d557d8d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17457254 16714083 |
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