Effects of 6-Week Use of Reduced-Nicotine Content Cigarettes in Smokers With and Without Elevated Depressive Symptoms
| العنوان: | Effects of 6-Week Use of Reduced-Nicotine Content Cigarettes in Smokers With and Without Elevated Depressive Symptoms |
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| المؤلفون: | David J. Drobes, Lauren R. Pacek, Eric C. Donny, Ryan Vandrey, Neal L. Benowitz, Andrine Lemieux, Rachel L. Denlinger, Rachel N. Cassidy, Mustafa al'Absi, Sarah S. Dermody, Jennifer W. Tidey, Natalie Nardone, Dorothy K. Hatsukami, Joseph S. Koopmeiners |
| المصدر: | Tidey, JW; Pacek, LR; Koopmeiners, JS; Vandrey, R; Nardone, N; Drobes, DJ; et al.(2017). Effects of 6-Week Use of Reduced-Nicotine Content Cigarettes in Smokers With and Without Elevated Depressive Symptoms.. Nicotine Tob Res, 19(1), 59-67. doi: 10.1093/ntr/ntw199. UCSF: Retrieved from: http://www.escholarship.org/uc/item/69d9z7xfTest |
| بيانات النشر: | Oxford University Press (OUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, Nicotine, medicine.medical_specialty, medicine.medical_treatment, 030508 substance abuse, Smoking Prevention, Craving, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Humans, 030212 general & internal medicine, Young adult, Depression (differential diagnoses), Original Investigation, Psychiatric Status Rating Scales, Depression, business.industry, Smoking, Public Health, Environmental and Occupational Health, Tobacco Products, Tobacco Use Disorder, Middle Aged, Center for Epidemiologic Studies Depression Scale, Clinical trial, Diagnosis, Dual (Psychiatry), Smoking cessation, Female, Smoking Cessation, medicine.symptom, 0305 other medical science, business, medicine.drug |
| الوصف: | Author(s): Tidey, Jennifer W; Pacek, Lauren R; Koopmeiners, Joseph S; Vandrey, Ryan; Nardone, Natalie; Drobes, David J; Benowitz, Neal L; Dermody, Sarah S; Lemieux, Andrine; Denlinger, Rachel L; Cassidy, Rachel; al'Absi, Mustafa; Hatsukami, Dorothy K; Donny, Eric C | Abstract: BackgroundThe FDA recently acquired regulatory authority over tobacco products, leading to renewed interest in whether reducing the nicotine content of cigarettes would reduce tobacco dependence in the United States. Given the association between depressive symptoms and cigarette smoking, it is important to consider whether smokers with elevated depressive symptoms experience unique benefits or negative consequences of nicotine reduction.MethodsIn this secondary analysis of a randomized clinical trial that examined the effects of cigarettes varying in nicotine content over a 6-week period in non-treatment-seeking smokers, we used linear regression to examine whether baseline depressive symptom severity (scores on the Center for Epidemiologic Studies Depression Scale [CES-D]) moderated the effects of reduced-nicotine content (RNC) cigarettes, relative to normal-nicotine content (NNC) cigarettes, on smoking rates, depressive symptom severity, and related subjective and physiological measures.ResultsOf the 717 participants included in this analysis, 109 (15.2%) had CES-D scores ≥ 16, indicative of possible clinical depression. Relative to NNC cigarettes, RNC cigarettes reduced smoking rates, nicotine dependence, and cigarette craving, and these effects were not significantly moderated by baseline CES-D score. A significant interaction between baseline CES-D score and cigarette condition on week 6 CES-D score was observed (p l .05); among those with CES-D scores ≥ 16 at baseline, those assigned to RNC cigarettes had lower week 6 CES-D scores than those assigned to NNC cigarettes. Among those in the lowest nicotine content conditions, biochemically confirmed compliance with the RNC cigarettes was associated with an increase in CES-D score for those with baseline CES-D scores l 16 and no change in CES-D score for those with baseline CES-D scores ≥ 16.ConclusionsThese findings provide initial evidence that a reduced-nicotine standard for cigarettes may reduce smoking, without worsening depressive symptoms, among smokers with elevated depressive symptoms.ImplicationsThis secondary analysis of a recent clinical trial examined whether depressive symptom severity moderated the effects of reduced-nicotine cigarettes on smoking and depressive symptoms. Results indicate that, regardless of baseline depressive symptoms, participants randomized to reduced-nicotine cigarettes had lower smoking rates, nicotine intake, nicotine dependence, and craving at week 6 post-randomization than those assigned to normal-nicotine cigarettes. In participants with higher baseline depressive symptoms, those assigned to reduced-nicotine cigarettes had lower week 6 depressive symptoms than those assigned to normal-nicotine cigarettes. These results suggest that a nicotine reduction policy could have beneficial effects for smokers, regardless of depressive symptom severity. |
| وصف الملف: | application/pdf |
| تدمد: | 1469-994X 1462-2203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f465b6fa6d9fb8dce81c1f37d80b41b0Test https://doi.org/10.1093/ntr/ntw199Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f465b6fa6d9fb8dce81c1f37d80b41b0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1469994X 14622203 |
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