Did Introducing a New Category of Thyroid Tumors (Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features) Decrease the Risk of Malignancy for the Diagnostic Categories in the Bethesda System for Reporting Thyroid Cytopathology?
| العنوان: | Did Introducing a New Category of Thyroid Tumors (Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features) Decrease the Risk of Malignancy for the Diagnostic Categories in the Bethesda System for Reporting Thyroid Cytopathology? |
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| المؤلفون: | Iwona Pałyga, Artur Kowalik, Kornelia Niemyska, Aldona Kowalska, Agnieszka Walczyk, Agnieszka Suligowska, Janusz Kopczyński, Danuta Gąsior-Perczak, Ryszard Mężyk, Kinga Hińcza, Stanisław Góźdź |
| المصدر: | Endocrine Pathology. 31:143-149 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Thyroid nodules, medicine.medical_specialty, Cytodiagnosis, Endocrinology, Diabetes and Metabolism, Biopsy, Fine-Needle, Bethesda system, 030209 endocrinology & metabolism, medicine.disease_cause, Pathology and Forensic Medicine, Papillary thyroid cancer, Thyroid carcinoma, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Adenocarcinoma, Follicular, medicine, Humans, Thyroid Neoplasms, Thyroid cancer, Thyroid neoplasm, Aged, Retrospective Studies, Suspicious for Malignancy, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Bethesda system for reporting thyroid cytopathology, Thyroid Cancer, Papillary, 030220 oncology & carcinogenesis, Female, Radiology, business |
| الوصف: | In 2016, Nikiforov et al. (JAMA Oncol 2:1023-1029, 2016) proposed replacing the term "non-invasive encapsulated follicular variant of papillary thyroid carcinoma" (FVPTC) with the term "non-invasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP). In 2018, to avoid the misdiagnosis of papillary thyroid cancer as NIFTP, the authors proposed changes to the criteria for NIFTP classification. Some previous studies evaluated the impact of NIFTP on the risk of malignancy (ROM) in the fine-needle aspiration cytology (FNAC) diagnostic categories according to the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). However, little is known about the influence of an NIFTP diagnosis on ROM on the basis of the revised criteria. The aim of this study was to assess the influence of NIFTP on ROM using the revised diagnostic criteria. The present study included 998 thyroid nodules that were diagnosed and resected at the same medical center. All specimens with a diagnosis of cancer were reviewed to identify NIFTP according to the revised 2018 criteria. Additionally, molecular diagnostics were performed to detect the BRAF p.V600E mutation and TERT promoter mutations in all the NIFTP cases. The number of cases that met the revised criteria was determined, and the ROM was calculated in each of the FNAC diagnostic categories. Only five cases (2.3% of all papillary thyroid carcinoma diagnoses) were considered NIFTP, according to the 2018 criteria. With respect to the FNAC category, one case was a follicular neoplasm or suspicious for a follicular neoplasm (FN/SFN), three cases were suspicious for malignancy (SM), and one case was malignant (M). The ROM decreased in each of the Bethesda categories (0.7% in FN/SFN, 4.3% in SM, and 0.5% in M) when a diagnosis of NIFTP was taken into account. These reductions were not statistically significant. These data indicate that the NIFTP entity has very little impact on ROM for the diagnostic categories of the Bethesda system. |
| تدمد: | 1559-0097 1046-3976 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ee7354d340158685bbc0c1aca02da9Test https://doi.org/10.1007/s12022-020-09619-0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f3ee7354d340158685bbc0c1aca02da9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590097 10463976 |
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