Blood Glucose Control in Type 1 Diabetes With a Bihormonal Bionic Endocrine Pancreas
| العنوان: | Blood Glucose Control in Type 1 Diabetes With a Bihormonal Bionic Endocrine Pancreas |
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| المؤلفون: | Kendra L. Magyar, John Jiang, Edward R. Damiano, David M. Nathan, Steven Russell, El-Khatib Firas H |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Hypoglycemia, Glucagon, 03 medical and health sciences, Islets of Langerhans, 0302 clinical medicine, Bolus (medicine), Diabetes mellitus, Blood Glucose Self-Monitoring, Internal medicine, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Glycemic, Original Research, 2. Zero hunger, Advanced and Specialized Nursing, Type 1 diabetes, business.industry, Insulin, Clinical Care/Education/Nutrition/Psychosocial Research, medicine.disease, 3. Good health, Endocrinology, Diabetes Mellitus, Type 1, Female, business |
| الوصف: | OBJECTIVE To test whether safe and effective glycemic control could be achieved in type 1 diabetes using a bihormonal bionic endocrine pancreas driven by a continuous glucose monitor in experiments lasting more than two days and including six high-carbohydrate meals and exercise as challenges to glycemic control. RESEARCH DESIGN AND METHODS Six subjects with type 1 diabetes and no endogenous insulin secretion participated in two 51-h experiments. Blood glucose was managed with a bionic endocrine pancreas controlling subcutaneous delivery of insulin and glucagon with insulin pumps. A partial meal-priming bolus of insulin (0.035 units/kg/meal, then 0.05 units/kg/meal in repeat experiments) was administered at the beginning of each meal (on average 78 ± 12 g of carbohydrates per meal were consumed). Plasma glucose (PG) control was evaluated with a reference quality measurement on venous blood every 15 min. RESULTS The overall mean PG was 158 mg/dL, with 68% of PG values in the range of 70–180 mg/dL. There were no significant differences in mean PG between larger and smaller meal-priming bolus experiments. Hypoglycemia (PG CONCLUSIONS A bihormonal bionic endocrine pancreas achieved excellent glycemic control with minimal hypoglycemia over the course of two days of continuous use despite high-carbohydrate meals and exercise. A trial testing a wearable version of the system under free-living conditions is justified. |
| اللغة: | English |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a5c47b3add05f74a9caf47b5967b0aTest http://europepmc.org/articles/PMC3476884Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f2a5c47b3add05f74a9caf47b5967b0a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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