Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study
| العنوان: | Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study |
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| المؤلفون: | Angela Galler, Nicole Noack, Wieland Kiess, Götz Gelbrich, Thomas Kapellen, Jürgen Kratzsch |
| المصدر: | European Journal of Endocrinology. 157:481-489 |
| بيانات النشر: | Oxford University Press (OUP), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Body Mass Index, Sex Factors, Endocrinology, Internal medicine, Diabetes mellitus, Humans, Medicine, Longitudinal Studies, Child, Type 1 diabetes, Adiponectin, business.industry, Age Factors, Case-control study, General Medicine, medicine.disease, Lipids, Obesity, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Case-Control Studies, Child, Preschool, Metabolic control analysis, Regression Analysis, Female, business, Body mass index |
| الوصف: | Objective: Adiponectin plays an important role in pathophysiology of obesity, type 2 diabetes and cardiovascular disease. The aim of this study was to determine adiponectin concentrations in children and adolescents with type 1 diabetes in a longitudinal manner and to study the impact of age, gender, body mass index (BMI) and metabolic control. Research design and methods: In this study, 88 children and adolescents with type 1 diabetes were followed longitudinally. At baseline and during follow-up, serum levels of adiponectin were measured by enzyme-linked immunoassay and correlated with clinical data, HbA1c and lipids. Healthy children (n = 259) were chosen as a control group. Results: Serum adiponectin levels were significantly higher in children with type 1 diabetes compared with healthy children (13.1 vs 9.1 μg/ml at baseline, P < 0.001). Adiponectin concentrations inversely correlated with BMI s.d.s (P < 0.001). No significant difference of adiponectin levels regarding gender, diabetes duration or HbA1c was seen. Adiponectin concentrations decreased in males with type 1 diabetes during puberty (P = 0.03) while there was no significant change in females. In a subgroup of patients with new onset type 1 diabetes, adiponectin concentrations were not different from adiponectin levels in control subjects but increased during follow-up (P = 0.007). Stepwise multiple regression analysis showed that most important predictors of adiponectin levels in type 1 diabetes at the end of the study were adiponectin concentration at baseline (β = 0.574, P < 0.001) and BMI s.d.s (β = −0.302, P = 0.001, r2 = 0.56). Conclusions: Children and adolescents with type 1 diabetes have BMI-dependent elevated serum concentrations of adiponectin compared with healthy children. |
| تدمد: | 1479-683X 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14dedb42ee7856b0dd9c8dc53e797cbTest https://doi.org/10.1530/eje-07-0250Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f14dedb42ee7856b0dd9c8dc53e797cb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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