Regulation of hepatic genes related to lipid metabolism and antioxidant enzymes by sodium butyrate supplementation
| العنوان: | Regulation of hepatic genes related to lipid metabolism and antioxidant enzymes by sodium butyrate supplementation |
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| المؤلفون: | Saeko Takami, Kazue Honma, Toshinao Goda, Kaho Oshima |
| المصدر: | Metabolism Open Metabolism Open, Vol 7, Iss, Pp 100043-(2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, Antioxidant, medicine.medical_treatment, NaB, sodium butyrate, NASH, non-alcoholic steatohepatitis, HDAC, histone deacetylase, Butyrate, SCFAs, short-chain fatty acids, lcsh:Physiology, lcsh:Biochemistry, chemistry.chemical_compound, ROS, reactive oxygen species, Internal medicine, medicine, Ingestion, lcsh:QD415-436, Non-alcoholic steatohepatitis (NASH), Beta oxidation, Fatty acid synthesis, lcsh:QP1-981, Sodium butyrate, Lipid metabolism, General Medicine, medicine.disease, Original Research Paper, Endocrinology, chemistry, Liver, Steatohepatitis |
| الوصف: | Background: Rapid influx of energy caused by fasting/refeeding repeatedly enhances fatty acid synthesis leading to triacylglycerol accumulation and production of reactive oxygen species (ROS), increasing the risk of non-alcoholic steatohepatitis (NASH). Previous studies have reported that the ingestion of butyrate is effective at preventing hepatic disorders, which are accompanied by fat accumulation and inflammation. The aim of this study is to reveal the mechanism of action of butyrate, and thus we investigated the effects of dietary butyrate on the expressions of antioxidant enzymes in the livers of rats during refeeding following fasting. Methods: Thirty-seven male rats were divided into six groups (6–7 animals per group): non-fasting, fasting, refeeding with a high sucrose diet as control for 12 or 24 h, and refeeding with a high sucrose diet containing 5% sodium butyrate (NaB) for 12 or 24 h. All groups except the non-fasting group were fasted for 72 h before refeeding. Statistical analysis was conducted among 4 refeeding groups (refeeding with the control diet for 12 or 24 h, and refeeding with a diet containing NaB for 12 or 24 h). Results: Supplementation with NaB significantly reduced (p |
| تدمد: | 2589-9368 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f140eed2a39d2d480edbe3bc327e8656Test https://pubmed.ncbi.nlm.nih.gov/32812944Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f140eed2a39d2d480edbe3bc327e8656 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25899368 |
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