Predicting invasiveness and disease-specific survival in upper tract urothelial carcinoma: identifying relevant clinical tumour characteristics
| العنوان: | Predicting invasiveness and disease-specific survival in upper tract urothelial carcinoma: identifying relevant clinical tumour characteristics |
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| المؤلفون: | Alexandra Grahn, Bernhard Tribukait, Georg Jaremko, Marianne Brehmer, Camilla Malm |
| المصدر: | World Journal of Urology |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Oncology, Nephrology, medicine.medical_specialty, Staging, Survival, Urology, 030232 urology & nephrology, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, Ureteroscopy, medicine, Humans, Neoplasm Invasiveness, Prospective Studies, Stage (cooking), Prospective cohort study, Diagnostics, Survival analysis, Aged, Aged, 80 and over, Carcinoma, Transitional Cell, Ureteral Neoplasms, business.industry, Radical nephroureterectomy, Middle Aged, Topic Paper, Kidney Neoplasms, Regression, Survival Rate, Exact test, Disease-specific survival, Upper tract, Upper tract urothelial carcinoma, 030220 oncology & carcinogenesis, Cohort, Female, business |
| الوصف: | Purpose The aim of this prospective study was to identify the tumour characteristics that are associated with invasiveness and those that are relevant for disease-specific survival (DSS) in upper tract urothelial carcinoma, UTUC. Methods From a prospective consecutive cohort of patients with suspicion of UTUC, those who were diagnosed with UTUC using URS prior to rNU between 2005 and 2012 were included. Tumour characteristics were analysed for prediction of invasiveness and association with DSS. Stages were categorised as superficial (pTa-1 and CIS only) or invasive (≥ pT2). Tumours were graded according to WHO 1999 classification. DSS was analysed regarding possible association with stage, grade, size, multifocality, location, ploidy and rate of proliferation. Associations were tested using Fisher’s exact test, Pearson Chi-square or Cox’s regression. Kaplan–Meier survival curves were constructed. Results Forty-five consecutive patients were included, and 43 of them were included in the final analyses because their rNU specimens were available for reassessment. The only tumour characteristics that were significantly associated with stage were tumour grade (P |
| تدمد: | 1433-8726 0724-4983 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12982723fcdc1d954945f63ebf4f4bbTest https://doi.org/10.1007/s00345-019-02760-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f12982723fcdc1d954945f63ebf4f4bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14338726 07244983 |
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