Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats
| العنوان: | Watermelon rind ethanol extract exhibits hepato-renal protection against lead induced-impaired antioxidant defenses in male Wistar rats |
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| المؤلفون: | O. Bamidele, Olugbenga Samuel Michael, Charles Oluwaseun Adetunji, Olufemi Idowu Oluranti, Pamela Ogheneovo, Temitope A. Ariyo, F.O. Awobajo, Lawrence Dayo Adedayo, Elizabeth O. Soladoye |
| المصدر: | Current Research in Physiology, Vol 4, Iss, Pp 252-259 (2021) Current Research in Physiology |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Antioxidant, Physiology, medicine.medical_treatment, GPx, Glutathione Peroxidase, rpm, revolutions per minute, Specialties of internal medicine, Environmental pollution, Pharmacology, chemistry.chemical_compound, Watermelon, medicine, QP1-981, GSH, Reduced Glutathione, MDA, Malondialdehyde, Liver injury, LDH, Lactate Dehydrogenase, Nitric oxide, General Medicine, Glutathione, medicine.disease, Malondialdehyde, Pb, Lead Acetate, ALP, Alkaline Phosphatase, chemistry, RC581-951, Lead acetate, Oxidative stress, Toxicity, Uric acid, AST, Aspartate Transaminase, ALT, Alanine Transferase, Research Paper, WM, Watermelon rind extract |
| الوصف: | Lead acetate associated tissue injury has been linked to altered antioxidant defenses, hyperuricemia and inflammation. We hypothesized that watermelon rind extract, would ameliorate lead acetate-induced hepato-renal injury. Thirty Male Wistar rats received distilled water, lead acetate (Pb; 5 mg/kg) with or without watermelon rind extract (WM; 400 mg/kg; WM + Pb; 15 days of WM pretreatment); Pb + WM (15 days of WM post treatment) and simultaneous treatment (WM-Pb) for 30 days. Lead toxicity led to elevated serum malondialdehyde, creatinine, urea, uric acid, lactate dehydrogenase, liver injury enzymes, as well as decreased body weight. Decreased serum levels of reduced glutathione, nitric oxide, total protein and glutathione peroxidase activity was also observed. However, these alterations were ameliorated by watermelon rind extract in lead acetate-treated rats. Watermelon rind ethanol extract protects against lead acetate-induced hepato-renal injury through improved antioxidant defenses at least in part, via uric acid/nitric oxide-dependent pathway signifying the health benefits of this agricultural waste and a potential for waste recycling while limiting environmental pollution. Highlights • Lead acetate leads to oxidative stress in liver and kidney. • Watermelon rind extract improved the antioxidants status via uric acid/nitric oxide-dependent pathway. • Watermelon rind extract confers hepato-renal protection. |
| اللغة: | English |
| تدمد: | 2665-9441 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f109d3aa2807980a87ad5190908bae87Test http://www.sciencedirect.com/science/article/pii/S2665944121000304Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f109d3aa2807980a87ad5190908bae87 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26659441 |
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