Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: role of enhanced low grade inflammation
| العنوان: | Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: role of enhanced low grade inflammation |
|---|---|
| المؤلفون: | Robin P. F. Dullaart, Eke G. Gruppen, Sander Kersten |
| المساهمون: | Lifestyle Medicine (LM) |
| المصدر: | Lipids in Health and Disease Lipids in Health and Disease 17 (2018) Lipids in Health and Disease, 17 Lipids in Health and Disease, 17(60). BioMed Central Ltd. Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-8 (2018) |
| بيانات النشر: | BioMed Central, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Glucose, Male, CHOLESTERYL ESTER TRANSFER, Angiopoietin-like4, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, 030204 cardiovascular system & hematology, MELLITUS, chemistry.chemical_compound, Voeding, Metabolisme en Genomica, 0302 clinical medicine, Endocrinology, High-density lipoprotein, Phospholipid transfer protein activity, ANGPTL4, Phospholipid transfer protein, Medicine, High sensitivity C-reactive protein, Phospholipid Transfer Proteins, lcsh:RC620-627, Lipoprotein lipase, Middle Aged, INSULIN, Metabolism and Genomics, DEFICIENCY, lcsh:Nutritional diseases. Deficiency diseases, C-Reactive Protein, CARDIOVASCULAR-DISEASE, Metabolisme en Genomica, Nutrition, Metabolism and Genomics, Female, FATTY-ACIDS, medicine.medical_specialty, Clinical chemistry, LIPOPROTEIN-LIPASE, 03 medical and health sciences, NEFA, Voeding, Internal medicine, Type 2 diabetes mellitus, Angiopoietin-Like Protein 4, Humans, Triglycerides, VLAG, Nutrition, Aged, Inflammation, Triglyceride, business.industry, Insulin, Research, Biochemistry (medical), Cholesterol, HDL, MICE, 030104 developmental biology, chemistry, Diabetes Mellitus, Type 2, PLTP, INNATE IMMUNITY, business, Non-esterified fatty acids |
| الوصف: | Background: Angiopoietin-like 4 (ANGPTL4) inhibits lipoprotein lipase, whereas phospholipid transfer protein (PLTP) enhances hepatic triglyceride secretion. Both factors may be upregulated by inflammatory pathways. Since the extent to which these circulating factors are interrelated is unknown, we determined the relationship between plasma ANGPTL4 and PLTP activity, and assessed whether such a relationship could be explained by high sensitivity C-reactive protein (hsCRP) levels as a marker of low-grade chronic inflammation.Methods: Fasting plasma ANGPTL4, PLTP activity (liposome-vesicle high density lipoprotein system) and hsCRP were measured in 41 type 2 diabetic (T2DM) subjects and 36 non-diabetic subjects.Results: Plasma ANGPTL4 and PLTP activity were increased in T2DM (p Conclusions: In conclusion, plasma ANGPTL4 and PLTP activity are interrelated, which may at least in part be explained by low-grade chronic inflammation. A pro-inflammatory state could affect triglyceride metabolism via concerted effects on ANGPTL4 and PLTP. |
| وصف الملف: | application/pdf; application/octet-stream |
| اللغة: | English |
| تدمد: | 1476-511X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09f50306a50e83a1b7988f691f46906Test http://europepmc.org/articles/PMC5870514Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f09f50306a50e83a1b7988f691f46906 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1476511X |
|---|