Pattern of treatment failures in patients with central nervous system non-germinomatous germ cell tumors (CNS-NGGCT): A pooled analysis of clinical trials
| العنوان: | Pattern of treatment failures in patients with central nervous system non-germinomatous germ cell tumors (CNS-NGGCT): A pooled analysis of clinical trials |
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| المؤلفون: | Fonseca, Adriana, Faure-Conter, Cecile, Murray, Matthew J, Fangusaro, Jason, Bailey, Shivani, Goldman, Stewart, Khatua, Soumen, Frappaz, Didier, Calaminus, Gabriele, Dhall, Girish, Nicholson, James C, Bouffet, Eric, Bartels, Ute |
| المساهمون: | Fonseca, Adriana [0000-0002-6382-6833], Faure-Conter, Cecile [0000-0002-4717-4943], Murray, Matthew J [0000-0002-4480-1147], Fangusaro, Jason [0000-0003-3099-5259], Bailey, Shivani [0000-0002-4749-244X], Goldman, Stewart [0000-0003-0134-1352], Khatua, Soumen [0000-0001-6416-650X], Frappaz, Didier [0000-0002-3684-9909], Calaminus, Gabriele [0000-0002-7893-7982], Dhall, Girish [0000-0002-4918-0167], Bouffet, Eric [0000-0002-6832-6539], Bartels, Ute [0000-0003-2112-5251], Apollo - University of Cambridge Repository |
| المصدر: | Neuro Oncol |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | relapse, Central Nervous System, Cancer Research, Brain Neoplasms, Neoplasms, Germ Cell and Embryonal, NGGCT, Central Nervous System Neoplasms, Oncology, Biomarkers, Tumor, intracranial germ cell tumors, Humans, Treatment Failure, Neurology (clinical), CNS, Neoplasm Recurrence, Local, Pediatric Neuro-Oncology, Retrospective Studies |
| الوصف: | Background Central Nervous System Non-Germinomatous Germ Cell Tumors (CNS-NGGCT) are rare but curable tumors. Due to their rarity, patients with treatment failures remain a poorly characterized group with unfavorable outcomes. In this study, we sought to characterize patients with treatment failures in a large, prospectively treated cohort. Methods European and North American clinical trials for patients with CNS-NGGCT (SIOP-GCT-96, SFOP-TGM-TC 90/92, COG-ACNS0122, and COG-ACNS1123) were pooled for analysis. Additionally, patients included and treated in the UK and France national registries under strict protocol guidelines were included as an independent, non-overlapping cohort. Results A total of 118 patients experienced a treatment failure. Twenty-four patients had progressive disease during therapy, and additional 11 patients were diagnosed with growing teratoma syndrome (GTS). Patients with GTS are significantly younger and present with local failures and negative tumor markers. Eighty-three individuals experienced disease relapses after treatment ended. Patients’ metastatic relapses presented significantly earlier than local relapses and were associated with tumor marker elevation (OR: 4.39; P = .026). In our analysis, focal or whole-ventricular radiation therapy was not associated with an increased risk of metastatic relapses. Conclusions Herein, we present the largest pooled dataset of prospectively treated patients with relapsed CNS-NGGCT. Our study identified younger age and negative tumor markers to be characteristic of GTS. Additionally, we elucidated that metastatic relapses occur earlier than local relapses are associated with elevated tumor markers and are not associated with the field of radiation therapy. These findings are of utmost importance for the planning of future clinical trials and the implementation of surveillance strategies in these patients. |
| وصف الملف: | application/octet-stream |
| تدمد: | 1523-5866 1522-8517 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06c2b1a0e90cfa2d2398626af28e974Test https://doi.org/10.1093/neuonc/noac057Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f06c2b1a0e90cfa2d2398626af28e974 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15235866 15228517 |
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