Effects of delayed gastric emptying on postprandial glucose kinetics, insulin sensitivity, and β-cell function
| العنوان: | Effects of delayed gastric emptying on postprandial glucose kinetics, insulin sensitivity, and β-cell function |
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| المؤلفون: | Ananda Basu, Chiara Dalla Man, Ling Hinshaw, Rickey E. Carter, Michele Schiavon, Claudio Cobelli, Adil E. Bharucha, Rita Basu, Ashwini Mallad, Yogish C. Kudva |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 307:E494-E502 |
| بيانات النشر: | American Physiological Society, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Adolescent, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Young Adult, Insulin resistance, Insulin-Secreting Cells, Physiology (medical), Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Artificial endocrine pancreas, Type 1 diabetes, C-Peptide, Gastric emptying, business.industry, Articles, Middle Aged, Glucagon, medicine.disease, Pramlintide, Islet Amyloid Polypeptide, Kinetics, Glucose, Endocrinology, Postprandial, Gastric Emptying, Food, Hyperglycemia, Female, Insulin Resistance, business, Algorithms, medicine.drug |
| الوصف: | Controlling meal-related glucose excursions continues to be a therapeutic challenge in diabetes mellitus. Mechanistic reasons for this need to be understood better to develop appropriate therapies. To investigate delayed gastric emptying effects on postprandial glucose turnover, insulin sensitivity, and β-cell responsivity and function, as a feasibility study prior to studying patients with type 1 diabetes, we used the triple tracer technique C-peptide and oral minimal model approach in healthy subjects. A single dose of 30 μg of pramlintide administered at the start of a mixed meal was used to delay gastric emptying rates. With delayed gastric emptying rates, peak rate of meal glucose appearance was delayed, and rate of endogenous glucose production (EGP) was lower. C-peptide and oral minimal models enabled the assessments of β-cell function, insulin sensitivity, and β-cell responsivity simultaneously. Delayed gastric emptying induced by pramlintide improved total insulin sensitivity and decreased total β-cell responsivity. However, β-cell function as measured by total disposition index did not change. The improved whole body insulin sensitivity coupled with lower rate of appearance of EGP with delayed gastric emptying provides experimental proof of the importance of evaluating pramlintide in artificial endocrine pancreas approaches to reduce postprandial blood glucose variability in patients with type 1 diabetes. |
| تدمد: | 1522-1555 0193-1849 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8e134ee8ed07df08533ed485170ea7Test https://doi.org/10.1152/ajpendo.00199.2014Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ee8e134ee8ed07df08533ed485170ea7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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