Multinational Home Use of Closed-Loop Control Is Safe and Effective
| العنوان: | Multinational Home Use of Closed-Loop Control Is Safe and Effective |
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| المؤلفون: | Francis J. Doyle, Roberta Calore, Sue A. Brown, Satya Shanmugham, Eric Renard, Stacey M. Anderson, Daniel R. Cherñavvsky, Marc D. Breton, Simone Del Favero, Roy W. Beck, Bruce A. Buckingham, Wendy C. Bevier, Jordan E. Pinsker, Anne Farret, Isuru Dasanayake, Revital Nimri, Trang T. Ly, Daniela Bruttomesso, Craig Kollman, Patrick Keith-Hynes, Angelo Avogaro, Boris Kovatchev, Dan Raghinaru, Federico Boscari, Jerome Place, Paige K. Bradley, Claudio Cobelli, Moshe Phillip, John Lum, Eyal Dassau |
| المساهمون: | Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Diabetes Care Diabetes Care, American Diabetes Association, 2016, 39 (7), pp.1143-1150. ⟨10.2337/dc15-2468⟩ |
| بيانات النشر: | HAL CCSD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Pancreas, Artificial, medicine.medical_specialty, Internationality, Glucose control, Adolescent, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Hypoglycemia, Artificial pancreas, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Insulin Infusion Systems, Diabetes mellitus, Internal Medicine, Advanced and Specialized Nursing, medicine, Humans, Hypoglycemic Agents, Insulin, 030212 general & internal medicine, Glycemic, Aged, Type 1 diabetes, Home environment, business.industry, urogenital system, Blood Glucose Self-Monitoring, Home use, Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, Mobile Applications, 3. Good health, Surgery, Diabetes and Metabolism, The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes, Diabetes Mellitus, Type 1, Anesthesia, Female, Smartphone, business |
| الوصف: | OBJECTIVE To evaluate the efficacy of a portable, wearable, wireless artificial pancreas system (the Diabetes Assistant [DiAs] running the Unified Safety System) on glucose control at home in overnight-only and 24/7 closed-loop control (CLC) modes in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS At six clinical centers in four countries, 30 participants 18–66 years old with type 1 diabetes (43% female, 96% non-Hispanic white, median type 1 diabetes duration 19 years, median A1C 7.3%) completed the study. The protocol included a 2-week baseline sensor-augmented pump (SAP) period followed by 2 weeks of overnight-only CLC and 2 weeks of 24/7 CLC at home. Glucose control during CLC was compared with the baseline SAP. RESULTS Glycemic control parameters for overnight-only CLC were improved during the nighttime period compared with baseline for hypoglycemia (time CONCLUSIONS CLC running on a smartphone (DiAs) in the home environment was safe and effective. Overnight-only CLC reduced hypoglycemia and increased time in range overnight and increased time in range during the day; 24/7 CLC reduced hypoglycemia and increased time in range both overnight and during the day. Compared with overnight-only CLC, 24/7 CLC provided additional hypoglycemia protection during the day. |
| اللغة: | English |
| تدمد: | 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee53efb7e9f5fb3e8fe27e85b5d128cfTest https://hal.archives-ouvertes.fr/hal-01868149Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ee53efb7e9f5fb3e8fe27e85b5d128cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01495992 |
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