Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019
| العنوان: | Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019 |
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| المؤلفون: | Odile Pillet, Antoine Dewitte, Marie Lise Bats, Olivier Guisset, Claire Rigothier, Catherine Fleureau, Alexandre Boyer, Hadrien Rozé, Cédric Carrié, Renaud Prevel, Frédéric Vargas, Laurent Petit, Nahema Issa, Sandrine Dabernat, Sébastien Rubin, Antoine Garric, Olivier Joannes-Boyau, Charline Sazio, Hoang Nam Bui, Fabrice Camou, Didier Gruson, Christian Combe, Benjamin Clouzeau, Gaelle Mourissoux, Arthur Orieux |
| المساهمون: | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, CHU Bordeaux [Bordeaux], Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Admin, Oskar |
| المصدر: | Clinical Kidney Journal Clinical Kidney Journal, Oxford University Press, 2020, 13 (3), pp.354-361. ⟨10.1093/ckj/sfaa099⟩ Clinical Kidney Journal, 2020, 13 (3), pp.354-361. ⟨10.1093/ckj/sfaa099⟩ |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Glycosuria, medicine.medical_specialty, medicine.medical_treatment, critically ill patients, 030232 urology & nephrology, urologic and male genital diseases, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Interquartile range, Intensive care, Internal medicine, medicine, 030212 general & internal medicine, Renal replacement therapy, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Transplantation, Creatinine, urogenital system, business.industry, Acute kidney injury, COVID-19, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, acute tubular injury, female genital diseases and pregnancy complications, 3. Good health, acute kidney injury, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Nephrology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, acute interstitial nephritis, Albuminuria, Original Article, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.symptom, business, renal replacement therapy, Kidney disease |
| الوصف: | Background Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) frequency, severity and characterization in critically ill patients has not been reported. Methods Single-centre cohort performed from 3 March 2020 to 14 April 2020 in four intensive care units in Bordeaux University Hospital, France. All patients with COVID-19 and pulmonary severity criteria were included. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. A systematic urinary analysis was performed. The incidence, severity, clinical presentation, biological characterization (transient versus persistent AKI; proteinuria, haematuria and glycosuria) and short-term outcomes were evaluated. Results Seventy-one patients were included, with basal serum creatinine (SCr) of 69 ± 21 µmol/L. At admission, AKI was present in 8/71 (11%) patients. Median [interquartile range (IQR)] follow-up was 17 (12–23) days. AKI developed in a total of 57/71 (80%) patients, with 35% Stage 1, 35% Stage 2 and 30% Stage 3 AKI; 10/57 (18%) required renal replacement therapy (RRT). Transient AKI was present in only 4/55 (7%) patients and persistent AKI was observed in 51/55 (93%). Patients with persistent AKI developed a median (IQR) urine protein/creatinine of 82 (54–140) (mg/mmol) with an albuminuria/proteinuria ratio of 0.23 ± 20, indicating predominant tubulointerstitial injury. Only two (4%) patients had glycosuria. At Day 7 after onset of AKI, six (11%) patients remained dependent on RRT, nine (16%) had SCr >200 µmol/L and four (7%) had died. Day 7 and Day 14 renal recovery occurred in 28% and 52%, respectively. Conclusion Severe COVID-19-associated AKI is frequent, persistent, severe and characterized by an almost exclusive tubulointerstitial injury without glycosuria. |
| وصف الملف: | application/pdf |
| تدمد: | 2048-8513 2048-8505 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbc3aa4c6ce9f088b42b64530de47f2Test https://doi.org/10.1093/ckj/sfaa099Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....edbc3aa4c6ce9f088b42b64530de47f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20488513 20488505 |
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