Differences between patients with type 1 diabetes with optimal and suboptimal glycaemic control: A real‐world study of more than 30 000 patients in a US electronic health record database
| العنوان: | Differences between patients with type 1 diabetes with optimal and suboptimal glycaemic control: A real‐world study of more than 30 000 patients in a US electronic health record database |
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| المؤلفون: | Phillip R. Hunt, Steven V. Edelman, Jeremy Pettus, Katie Mercaldi, Sachin Paranjape, Fang Liz Zhou, Kellee M. Miller, Ronald Preblick, Leah Shepherd |
| المصدر: | Diabetes, Obesity & Metabolism Diabetes, obesity & metabolism, vol 22, iss 4 |
| بيانات النشر: | Blackwell Publishing Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Diabetic ketoacidosis, type 1 diabetes, Endocrinology, Diabetes and Metabolism, Clinical Sciences, computer.software_genre, Endocrinology & Metabolism, Endocrinology, cardiovascular disease, Diabetes mellitus, Health care, Internal Medicine, medicine, Electronic Health Records, Humans, Hypoglycemic Agents, Depression (differential diagnoses), Disease burden, Glycated Hemoglobin, Type 1 diabetes, database research, Database, business.industry, diabetes complications, Emergency department, Original Articles, medicine.disease, Hypoglycemia, United States, Diabetes Mellitus, Type 1, Original Article, observational study, Diagnosis code, business, computer, diabetes complications, database research, cardiovascular disease |
| الوصف: | Author(s): Pettus, Jeremy H; Zhou, Fang Liz; Shepherd, Leah; Mercaldi, Katie; Preblick, Ronald; Hunt, Phillip R; Paranjape, Sachin; Miller, Kellee M; Edelman, Steven V | Abstract: AimsTo use electronic health record data from real-world clinical practice to assess demographics, clinical characteristics and disease burden of adults with type 1 diabetes (T1D) in the United States.Materials and methodsRetrospective observational study of adults with T1D for ≥24 months at their first visit with a T1D diagnosis code ("index date") between July 2014 and June 2016 in the Optum Humedica database. Demographic characteristics, acute complications (severe hypoglycaemia [SH], diabetic ketoacidosis [DKA]), microvascular complications, cardiovascular (CV) events and health care resource utilization during the 12 months before the index date ("baseline period") were compared between patients with optimal versus suboptimal glycaemic control (glycated haemoglobin [HbA1c] l7.0% vs. ≥7.0% [53 mmol/mol]) at the closest measurement to the index date.ResultsOf 31 430 adults with T1D, 79.9% had suboptimal glycaemic control (mean HbA1c 8.8% [73 mmol/mol]). These patients were more likely to be younger, African American, uninsured or on Medicaid, obese, smokers, have uncontrolled hypertension and have depression. Despite worse glycaemic control and increased CV risk factors of uncontrolled hypertension, obesity and smoking, rates of coronary heart disease and stroke were not higher in these patients. Patients with suboptimal glycaemic control also experienced more diabetes complications (including SH, DKA and microvascular disease) and utilized more emergency care, with more emergency department visits and inpatient stays.ConclusionThis real-world study of g30 000 adults with T1D showed that individuals with suboptimal versus optimal glycaemic control differed significantly in terms of health care coverage, comorbidities, diabetes-related complications, health care utilization and CV risk factors. However, suboptimal control was not associated with increased risk of CV outcomes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1463-1326 1462-8902 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda0334a948d2d2201e92a7bf65f6776Test http://europepmc.org/articles/PMC7079022Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eda0334a948d2d2201e92a7bf65f6776 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14631326 14628902 |
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